Binge-Eating Disorder
Conditions
Keywords
Binge-Eating Disorder, Decision-Making, Brain Activity
Brief summary
The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.
Interventions
BEHAVIORALSpeaking Activity
Participants will engage in a speaking activity where they are given a topic to speak about.
BEHAVIORALTalking Activity
Participants will engage in a talking activity where they may talk about a topic of their choice.
Sponsors
Mclean Hospital
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion Criteria for All Participants: * Normal or corrected to normal vision and hearing * Verbal and written fluency in English * Right-handed * Body mass index of 20-35 kg/m\^2 Additional Inclusion Criteria for Participants with Binge-Eating Disorder: • DSM-5 binge-eating disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Decision-making behavior (actual decisions) | Up to 1 hour post-intervention | Decisions (i.e., percent of goal-inconsistent decisions from challenge trials) |
| Decision-related BOLD activation (reward regions-of-interest) | Up to 1 hour post-intervention | Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in reward (e.g., nucleus accumbens, insula) |
| Decision-related BOLD activation (executive function regions-of-interest) | Up to 1 hour post-intervention | Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in executive function (e.g., dorsolateral prefrontal cortex, inferior frontal gyrus) |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORKristin N Javaras, DPhil, PhD
Mclean Hospital
Outcome results
None listed