Obstructive Sleep Apnea Among Somali-Americans

Evaluating the Prevalence and Implications of Obstructive Sleep Apnea Among Somali-Americans: A Translational Research Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04124848

Acronym

Somali OSA

Enrollment

600

Registered

2019-10-11

Start date

2019-10-25

Completion date

2031-12-31

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Keywords

Somali-Americans, Sleep Disordered Breathing, Cardiovascular Diseases, Sex and Racial Differences, Respiratory Disorders, Hypertension, Diabetes, Health Disparities

Brief summary

The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.

Detailed description

Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Self-identify as Somali, African, Asian, and European descent. * Adult males and females who are older than 18 years of age.

Exclusion criteria

* Minors under 18 years or adults over 100 years * Positive pregnancy

Design outcomes

Primary

Measure	Time frame	Description
To assess the prevalence of obstructive sleep apnea	10 years	Measure the apnea-hypopnea index (AHI) to determine burden of obstructive sleep apnea. Based on the AHI, sleep apnea will be diagnosed if the AHI is ≥5 events/hour.
To determine the severity of obstructive sleep apnea	10 years	The severity of OSA is classified based on the AHI as follows: None/Minimal: AHI \< 5 per hour, Mild: AHI ≥ 5, but \< 15 per hour, Moderate: AHI ≥ 15, but \< 30 per hour, Severe: AHI ≥ 30 per hour.

Secondary

Measure	Time frame	Description
Vascular endothelial function	10 years	Change in brachial artery diameter in response to hyperemia
Insulin sensitivity	10 years	Oral glucose tolerance testing
Body composition	10 years	Percentage body fat content
24 hour mean arterial pressure	10 years	Ambulatory measure of blood pressure in mmHg

Countries

United States

Contacts

Primary ContactSomers CPL Lab

CPLSOMALI@mayo.edu507-422-3499

Outcome results