Post-operative Endodontic Pain
Conditions
Brief summary
Two drugs (Piroxicam and Prednisolone)are being compared for post operative endodontic pain after a single visit root canal treatment for 74 hours.
Detailed description
To evaluate effectiveness of single dose premedication with piroxicam(20mg) and prednisolone(20mg) on post endodontic pain after a single visit root canal treatment . patient will be recalled every day for 4 days to know the pain scale using visual analogue scale .
Interventions
DRUGPiroxicam 20 mg
Piroxicm is from oxicam family of anti inflammatory drug that inhibits prostaglandin synthesis and effectively lower pain threshold levels
prednisolone is from steroid family of anti inflammatory drug that inhibit arachidonic acid and effectively lowers the pain
Sponsors
Dow University of Health Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Masking description
It is a double blinded study in which investigator /caregiver and participant will be blinded and 3rd person not in the study will be dispatching drugs from the coded bottles .
Intervention model description
subjects are randomly placed into one of the three groups: Placebo, Piroxicam (20 mg), Prednisolone (20 mg). The drugs will be given thirty minutes before procedure starts,followed by one visit root canal procedure. Postoperative pain will be evaluated up to 96 hours interval using a visual analog scale.
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
1. Patient ages from 20-40 years(28). 2. Single rooted tooth with symptomatic irreversible pulpitis. 3. With no analgesic or anti-inflammatory drug taken within a week period before procedure.
Exclusion criteria
1. Patients presenting with any systemic disease 2. Patients already taking premedication for endodontic pain. 3. Pregnant or lactating patients. 4. Multirooted teeth. 5. Teeth with Pulpal necrosis. 6. Previously treated or initiated root canal treatment. 7. Patient presenting with allergy due to drug
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| post operative pain | 76 hours | post operative pain will be measured after single visit endodontic treatment using visual analog scale with readings 1 to 10 from 24 hours till 76 hours |
Countries
Pakistan
Outcome results
None listed