High Caries Experience, Low Caries Experience
Conditions
Keywords
caries experience, VDR, TFIP11, enviromental risk factor
Brief summary
VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.
Detailed description
To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits. TFIP11 and VDR genes are related to enamel formation genes
Interventions
GENETIChigh caries experience
DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit
Sponsors
Recep Tayyip Erdogan University Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
24 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* adult be between 24 and 40 years old * subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) DMFT≤4 , or, DMFT\>13.9
Exclusion criteria
* systemic or genetic disorders * orthodontic appliances * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| past caries experience | 3 weeks | Each tooth will be examined and recorded as decayed, missing, or filled |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plaque index | 3 weeks | The plaque amount is scored by using Silness&Löe Plaque Index plaque index PI\<1.0 healthy PI 1.1-2.0 mild PI\>2 high plaque |
Countries
Turkey (Türkiye)
Outcome results
None listed