Knee Osteoarthritis
Conditions
Brief summary
Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients. Mechanistic pain profiling aims to identify the underlying mechanisms in the peripheral and central nervous systems, which are associated to the clinical pain. In addition, the mechanisms underlying the pain relieving effect of standardized exercise therapy are largely unknown, but it is hypothesized that they are linked to the patient's ability to activate the descending pain inhibitory pathways (conditioned pain modulation, CPM) in the central nervous system. Mechanistic pain profiling including CPM have been used prognostic to identify responders to treatment, but these measures as a prognostic tool for standardized exercise therapy has not been investigated. The primary aim of this study is to investigate if mechanistic pain profiling alone or in combination with clinical pain measures before standardized exercise therapy can predict the patients' pain reduction following the exercise therapy program
Interventions
BEHAVIORALstandardized exercise therapy for knee OA patients
Standardized exercise therapy for 6-8 weeks (two times per week).
Sponsors
Aalborg University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The American College of Rheumatology for clinical knee osteoarthritis (excluding radiological OA assessment)
Exclusion criteria
* Known factors to influence pain and pain sensitization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pain reduction | 1-2 weeks after last exercise session | Pain measured on a numerical rating scale from 0 (no pain) to 10 (worst pain imaginable) |
Countries
Denmark
Outcome results
None listed