Vitamin A Deficiency
Conditions
Brief summary
Women of reproductive age had their vitamin A stores estimated by retinol isotope dilution and then were given vitamin A supplements near the US vitamin A RDA or placebo for 42(USA) or 60 (Indonesia) days, after which retinol isotope dilution was repeated and the change in vitamin A stores was determined in each group to estimate how much vitamin A is needed to maintain nutrient balance in these women.
Interventions
DIETARY_SUPPLEMENTVitamin A supplement
DIETARY_SUPPLEMENTPlacebo
Sponsors
National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
University of Wisconsin, Madison
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Masking description
Participants blinded (Indonesian), double blinded (USA)
Intervention model description
Parallel assignment to 0 or 525 micrograms supplemental vitamin A/day (Indonesia) or 0, 175 or 525 micrograms supplemental vitamin A/day (USA).
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal nutritional status (BMI 18.5-25)
Exclusion criteria
* Significant clinical illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total body vitamin A stores (micromoles of vitamin A) | Baseline and after 42 to 60 days | Change in total body stores of vitamin A before and after intervention, measured by retinol isotope dilution |
| Total vitamin A liver reserves (micromoles vitamin A per gram liver) | Baseline and after 42 to 60 days | Change in total liver reserves of vitamin A before and after intervention, measured by retinol isotope dilution |
Countries
Indonesia, United States
Outcome results
None listed