Copd
Conditions
Brief summary
The association of blood eosinophil as a biomarker for eosinophilic Thai COPD patients, such as COPD exacerbation, hospital admission, lung functions and mortlity.
Detailed description
The prospective one year study in Thai COPD patients for the clinical outcomes of COPD compare between eosinophilic and non-eosinophilic which determine by blood eosinophil counts equal or more than 300 cells/microliters. The primary outcomes was COPD exacerbation, the secondary outcomes were lung function, dyspnea and quality of life.
Interventions
OTHERobservatory
observation for 1 year period
Sponsors
Prince of Songkla University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of COPD by GOLD criteria
Exclusion criteria
1. high blood eosinophil from known causes such as systemic corticosteroid use, malignancy, parasitic infection 2. Patients who had previous acute exacerbation within 30-day before study entry 3. Patients who had previous systemic corticosteroids used within 30-day before study entry
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute worsening of respiratory symptoms | 1 year | acute severe worsening of respiratory symptoms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physiological outcomes | 1 year | Forced expiratory volume in one second |
| health related quality of life | 1 year | Chronic Obstructive Pulmonary Disease Assessment Test (CAT) scores which the minimum 0 and maximum 40 values, and whether higher scores mean a worse outcome. |
Countries
Thailand
Outcome results
None listed