Cardiovascular
Conditions
Keywords
Oxycodone, Sufentanil, tracheal intubation
Brief summary
To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).
Detailed description
Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR \[1.2\]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.
Interventions
DRUGOxycodone 10mg
induction with 0.3mg/kg of oxycodone in general anesthesia
DRUGSufentanil
induction with 0.3 µg/kg of Sufentanil in general anesthesia
Sponsors
Shengjing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
60 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
The coronary angiography from each patient showed that lesions exist in at least one main coronary artery
Exclusion criteria
a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP) | one second before anesthesia induction, the moment when tracheal catheter passes through glottis and at 1, 3, 5 min after tracheal intubation | Under local anesthesia invasive artery line was put to the patients to monitor systolic blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP) |
Countries
China
Outcome results
None listed