Healthy Aging
Conditions
Brief summary
This study will determine the effects of simultaneous exercise and cognitive training on cognitive function in healthy older adults. Specifically, this study will compare the use of a tablet-based cognitive training system while exercising with exercise alone, cognitive training alone, and a neutral control condition on cognition.
Interventions
BEHAVIORALNeutral video
Participants in this arm will engage in a 12-week intervention that involves watching neutral videos on a tablet computer three times per week.
BEHAVIORALSimultaneous exercise and cognitive training
Participants in this arm will engage in a 12-week intervention that combines physical exercise and cognitive tablet-based training. This intervention involves use of an exercise bicycle while engaging in cognitive tasks on a tablet computer three times per week.
BEHAVIORALExercise training
Participants in this arm will engage in a 12-week exercise intervention that involves use of an exercise bicycle three times per week.
BEHAVIORALCognitive Training
Participants in this arm will engage in a 12-week intervention that involves cognitive tablet-based training three times per week.
Sponsors
University of Arizona
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 74 Years
Healthy volunteers
Yes
Inclusion criteria
Generally healthy, age 60-74, and a written statement from their primary care physician indicating that they are able to participate in the 12-week exercise program.
Exclusion criteria
Subjects will be excluded from participating in the study if they express significant concerns about their memory or declines in other cognitive abilities, if they are not English speaking, or if they have histories of significant major neurological, psychiatric, or medical disorder or injury that would affect cognitive function.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in cognitive function during dual-task test at 12 weeks | Baseline and 12-weeks | Performance on serial subtraction during dual-task walking. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in stride duration during dual-task test | Baseline, 6 weeks, 12 weeks | The difference between stride duration in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks |
| Change from baseline in stride velocity during dual-task test | Baseline, 6 weeks, 12 weeks | The difference between stride velocity in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks |
| Change from baseline in stride length variability during dual-task test | Baseline, 6 weeks, 12 weeks | The difference between stride length variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks |
| Change from baseline in stride length during dual-task test | Baseline, 6 weeks, 12 weeks | The difference between stride length in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks |
| Change from baseline in stride velocity variability during dual-task test | Baseline, 6 weeks, 12 weeks | The difference between stride velocity variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks |
| Change from baseline in cognitive function during dual-task test at 6 weeks | Baseline and 6-weeks | Performance on serial subtraction during dual-task walking. |
| Change from baseline in stride duration variability during dual-task test | Baseline, 6 weeks, 12 weeks | The difference between stride duration variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Deary-Liewald Reaction Time Task Simple median response time | Baseline, 6 weeks, 12 weeks | Tests to measure speed of information processing |
| Change from baseline in Wechsler Adult Intelligence Scale-IV Digit Span total score | Baseline, 6 weeks, 12 weeks | A measure of working memory |
| Change from baseline in Deary-Liewald Reaction Time Task Choice median correct response time | Baseline, 6 weeks, 12 weeks | Tests to measure speed of information processing |
| Change from baseline in Wechsler Adult Intelligence Scale-IV Coding total score | Baseline, 6 weeks, 12 weeks | A measure of information processing |
| Change from baseline in Wechsler Adult Intelligence Scale-IV Letter-Number Sequencing total score | Baseline, 6 weeks, 12 weeks | A measure of working memory |
| Change from baseline in Wechsler Memory Scale-IV Paired-Associates I total score | Baseline, 6 weeks, 12 weeks | A measure of verbal learning |
| Change from baseline in Auditory Verbal Learning Test total learning score | Baseline, 6 weeks, 12 weeks | A test of verbal list learning |
| Change from baseline in Trail Making Test, part A total time | Baseline, 6 weeks, 12 weeks | Tests of visuomotor tracking and complex attention |
| Change from baseline in Trail Making Test, part B total time | Baseline, 6 weeks, 12 weeks | Tests of visuomotor tracking and complex attention |
| Change from baseline in Stroop Color and Word Test Color/Word Interference total score | Baseline, 6 weeks, 12 weeks | A test to assess inhibition when reading color words |
Outcome results
None listed