Short Bowel Syndrome, Hyperoxaluria, Hyperoxalemia
Conditions
Brief summary
Hyperoxaluria due to fat malabsorption is seen in patients suffering from short bowel and can lead to stones and nephrocalcinosis. Not all patients are prone to these renal complications. only urinary oxaluria is measured in practice. Plasma oxalate shouldn't increase theoretically in these patients. However recent report showed an increase of plasma oxalate in patient with enteric hyperoxaluria. The aim of this study is to assess the plasma oxalate distribution in this specific population to have a new tool to predict renal complication of these patients.
Interventions
BIOLOGICALBlood sampling
blood sampling will be used to perform oxalemia and FGF23 quantitative analysis
BIOLOGICALUrine sampling
urine sampling will be used to measure glycolate urinary rate (glycolaturia) and to perform urinary inflammation markers quantitative analysis
PROCEDUREPulse Wave Velocity (PWV) measurement
PWV will be measured thank to the Complior® device
PROCEDUREcentral pressure measurement
central pressure will be measured thank to the Complior® device
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Type II short bowel for more than 6 months * Affiliated to a social health care
Exclusion criteria
* Primary hyperoxaluria * Other type of short bowel than type II * Minor patient or major patient protected by the law
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma oxalate rate (oxalemia) | at inclusion | this sample measures the plasma oxalate rate |
Countries
France
Outcome results
None listed