Autonomic Dysfunction
Conditions
Brief summary
To evaluate autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.
Detailed description
To evaluate the relationship between narcolepsy and sleep-disordered breathing, the natural course of untreated or treated sleep-disordered breathing and its impacts on autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.
Interventions
DIAGNOSTIC_TESTPolysomnography
overnight polysomnography recording at least six hours
DIAGNOSTIC_TESTMultiple sleep latency test
daytime naps at least four to five naps to evaluate daytime sleepiness and narcolepsy
OTHERContinuous positive airway pressure
continuous positive airway pressure treatment for sleep-disordered breathing
Sponsors
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* 7-75 y/o Prader-Willi syndrome patients or healthy subjects * can perform polysomnography, multiple sleep latency test * orthostatic methods for autonomic function test * can perform pulmonary function test.
Exclusion criteria
* less than y/o, or larger then 75 y/o * cannot perform polysomnography, multiple sleep latency test * cannot orthostatic methods for autonomic function test * cannot perform pulmonary function test * use of sedatives or drugs affecting autonomic function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Narcolepsy prevalence | 1day | Compare the narcolepsy prevalence amount healthy and Prader-Willi syndrome with or without sleep-disordered breathing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The natural course and its impact of untreated sleep-disordered breathing on autonomic regulation in patients with Prader-Willi syndrome. | 12 months | Autonomic function measurements (low frequency power and high frequency power, presented as normalized units, and the overall autonomic regulation presented as Low frequency/high frequency ratio) using the EKG signal extracting from overnight polysomnography recording raw data among Prader-Willi patients with untreated sleep-disordered breathing at baseline and after a period of follow-up. |
Other
| Measure | Time frame | Description |
|---|---|---|
| The effect of continuous positive airway pressure on autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing. | 3 months | 1. Acute effect (one-night continuous positive airway pressure trial): Compared the autonomic function measurements between baseline polysomnography and one night continuous positive airway pressure treatment in patients with Prader-Willi Syndrome and sleep-disordered breathing. 2. Chronic effect (at least 12 months treatment of continuous positive airway pressure) Compared the autonomic function measurements between baseline polysomnography and after at least 3 months continuous positive airway pressure treatment in patients with Prader-Willi Syndrome and sleep-disordered breathing. |
Countries
Taiwan
Contacts
Primary Contact美貞 楊, MD
Outcome results
None listed