Pulmonary Embolism
Conditions
Brief summary
The purpose of the study is to evaluate the value of biomarkers in the diagnosis and risk stratification of patients with suspected pulmonary embolism.
Detailed description
Management of patients with acute pulmonary embolism is a serious problem. The rapid and accurate diagnosis and risk stratification of these patients is an important unmet clinical need. The aim of the study is to evaluate the value of biomarkers, alone or in combination, in the diagnosis and risk stratification of patients with suspected pulmonary embolism presenting to the emergency department.
Interventions
None listed
Sponsors
Beijing Institute of Heart, Lung and Blood Vessel Diseases
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patient aged ≥ 18 years that presents to an emergency department * With suspected PE defined as new onset of or worsening of shortness of breath or chest pain
Exclusion criteria
* Hemodynamic instability * Life expectancy less than 3 months * First symptoms 15 day or more before inclusion * Inability to the follow-up visits * Therapeutic anticoagulation for any indication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Area under the ROC curve of biomarkers for the diagnosis of PE | 2 years | The ROC curve will be built, the area under the curve will be calculated with its confidence interval. |
| PE related death | 7 days | Number of PE related death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptomatic recurrent venous thromboembolic events | 2 years | Number of symptomatic recurrent venous thromboembolic event |
Countries
China
Contacts
Primary ContactYulin Li, PhD
Outcome results
None listed