REtinaL Imaging & Ambulatory BLood PrEssure

REtinaL Imaging & Ambulatory BLood PrEssure: Validating Ultra-widefield Retinal Imaging Derived Biomarkers Against Ambulatory Blood Pressure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04118205

Acronym

RELIABLE

Enrollment

591

Registered

2019-10-08

Start date

2019-01-20

Completion date

2021-05-04

Last updated

2022-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Pressure, Hypertension

Brief summary

High blood pressure is a common condition which generally does not have any symptoms. Its estimated that around one third of people with high blood pressure do not know they have it. The back of the eye called the retina is one of the few places in the human body allowing easy observation of blood vessels. This study aims to see if simple non-invasive imaging of the blood vessels of the retina will highlight people with high blood pressure.

Detailed description

This will be a prospective, single centre study recruiting patients who are attending the ambulatory blood pressure clinic at the Western General Hospital. Suitable patients will be approached, and if they consent will have pictures of the back of each of their eyes taken. These pictures will then be reviewed, with certain measurements taken of the small blood vessels which can been seen at the back of the eye. These measurements will then be compared to the participants blood pressure readings to see if they might accurately correlate to blood pressure.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Inclusion criteria

* Attending ambulatory blood pressure clinic * Able to undertake ambulatory BP measurement * Able to undertake single clinic-based BP measurement * Able to undergo UWF retinal imaging with a SLO * Aged 18 to 90 * Able to give informed consent

Exclusion criteria

* People with known history of retinal surgery * People under the age of 18 years. * People that cannot: manoeuvre themselves to the SLO unaided, sit upright in a chair or wheelchair or position themselves comfortably for imaging. * People with epilepsy

Design outcomes

Primary

Measure	Time frame	Description
Does retinal arteriovenous ratio correlate to systolic blood pressure	1 day	Retinal arteriovenous ratio (as measured by ultra-wide field imaging) will be correlated to mean daytime systolic blood pressure (as measured by 24-hour ambulatory blood pressure monitoring)

Secondary

Measure	Time frame	Description
Does retinal arteriovenous ratio correlate to clinic systolic blood pressure	1 day	Retinal arteriovenous ratio (as measured by ultra-wide field imaging) will be correlated to clinic systolic blood pressure.

Countries

United Kingdom

Outcome results