Intraoperative Hypotension, Perioperative Complication
Conditions
Brief summary
The aim of this study is to investigate the association between the severity and duration of intraoperative hypotension and the incidence of perioperative stroke after non-cardiac and non-neurologic surgeries.The secondary aim of this study is to confirm the potential risk factors of the perioperative stroke.
Detailed description
Optimized intraoperative management may play an important role in perioperative stroke prevention. Maintaining blood pressure near preoperative baseline values may help decrease the incidence of stroke, however the related evidence is limited.Therefore, this study is to investigate the association between intraoperative hemodynamic variable and the risk of perioperative stroke after non-cardiac and non-neurologic surgeries. The secondary aim of this study is to establish the potential risk factors of the perioperative stroke.
Interventions
BEHAVIORALPatiens with intraoperative hypotension
In this study, we will use four previously defined thresholds for intraoperative hypotension: two absolute thresholds (MAP less than 50 mmHg and MAP less than 60 mmHg) and two relative thresholds to the baseline MAP (a decrease of 30% or more and a decrease of 40% or more). A definition of baseline value most frequently reported was the arterial blood pressure before the induction of anesthesia. Therefore, the baseline MAP used in calculating the relative thresholds is defined as the mean MAP of all available blood pressure measurements before induction of anesthesia in the operating room.
Sponsors
Qianfoshan Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients underwent surgeries in First hospital affiliated to Shandong First Medical University from January 2013 to October 2019 2. Age\>18 or older
Exclusion criteria
1. Patients received local infiltration anesthesia 2. Patients underwent total intravenous anesthsia without tracheal intubation or Laryngeal Mask Airway insertion 3. Major vascular operation 4. Neurologic surgery 5. Cariac surgery 6. Intraoperative blood pressure measurements or postoperative neuroimagings measurements are not available 7. History of severe neurological or psychiatric disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of perioperative stroke | Within 24 hours after surgery | Perioperative stroke diagnosed with CT or MRI examination, symptoms and signs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of death | Within 24 hours after surgery | Death from any cause |
| Expense of Healthe care and social service | Through study completion, an average of 14 days | The expense of Healthe care and social service that the patients spent in hospital |
Countries
China
Contacts
Primary ContactYuelan Wang, Doctor
Outcome results
None listed