Prematurity; Extreme
Conditions
Brief summary
Pulmonary vascular disease and cardiac performance in extreme preterm infants: A prospective cross-sectional study
Detailed description
The principal investigator hypothesize that premature newborns have disturbed cardiac performance and increased pulmonary pressures during neonatal life and at different pediatric ages. The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes. The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes and that novel echocardiography techniques will detect anomalies not uncovered by conventional imaging, and that early echocardiography may identify those with later pulmonary hypertension.
Interventions
OTHEREchocardiography
Diagnostic test which uses ultrasound waves to make images of the heart chambers, valves and surrounding structures
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Days to 5 Years
Healthy volunteers
Yes
Inclusion criteria
* Infants born at \<29 weeks' gestational age admitted to the NICU * All infants born at \<29 weeks' gestational age followed at MCH clinic after an admission in the NICU for prematurity \<29 weeks
Exclusion criteria
* Congenital heart disease (except an atrial (ASD) or ventricular septal defect (VSD), or a patent ductus arteriosus (PDA)) * Congenital severe lung or airway malformation (choanal atresia, trachea-esophageal fistula or congenital pulmonary airway malformation) * Genetic disorder (Trisomy 21).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart function by echocardiography | 7-10 days of chronological age | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neuro-developmental profile | 7-10 days of chronological age | Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography |
Countries
Canada
Outcome results
None listed