Effect of 25-OH-vitamin D3 on the Liver Transplant Recipients

The Clinical Effect of Preoperative Level of 25-OH-vitamin D3 on the Liver Transplant Recipients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04111146

Enrollment

219

Registered

2019-10-01

Start date

2017-06-01

Completion date

2019-06-30

Last updated

2019-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplant Disorder

Keywords

vitamin D, liver transplant, hospital stay

Brief summary

The low vitamin D3 levels and malnutrition before liver transplantation showed an increase in the length of stay in ICU and hospital. Although several factors may influence the clinical outcomes of patients with liver transplantation, low vitamin D3 levels showed an independent risk factor. It is necessary to prospectively analyze the effect of vitamin D supplements on clinical outcomes in liver transplant recipients.

Detailed description

Purpose: Vitamin D deficiency is common in patients of chronic liver disease and has been associated with infection and mortality. The aim of this study is to determine whether preoperative vitamin D levels affect clinical outcomes after liver transplantation. Methods : This was a single-center retrospective study. Between June and November 2017, a total of 219 patients underwent liver transplantation. The primary outcome was the relationship between serum 25-OH-vitamin D3 level before liver transplantation and length of stay in the intensive care unit (ICU). Secondary outcomes included the duration of normalization of inflammatory marker, such as white blood cell count (WBC) & C-reactive protein (CRP) after liver transplantation, new infection rates, rejection rates, the length of hospital stay and mortality among vitamin D level.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* The patients who admitted to intensive care unit (ICU) after liver transplantation were studied

Exclusion criteria

* Patients who didn't have preoperative vitamin D level

Design outcomes

Primary

Measure	Time frame	Description
Hospital stay after liver transplant	6 months	compared with each group

Secondary

Measure	Time frame	Description
duration of normalization of CRP, WBC	6 months	compared with each group
Length of ICU stay	6 months	compared with each group
New infection rate	6 months	compared with each group

Countries

South Korea

Outcome results