Healthy
Conditions
Brief summary
The objective of this pilot study is to collect preliminary data using total body scans on a new, first of its kind, FDA 510k-cleared positron emission tomography/computed tomography (PET/CT) scanner, called EXPLORER.
Interventions
DEVICEEXPLORER PET/CT
Intervention: PET/CT using different protocols
Sponsors
University of California, Davis
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Men and women, 18 years of age or older * Willing and able to fast for at least 6 hours before and for the duration of the scan * Willing and able to lay motionless in a supine position for 60 and 20 minutes at separate timepoints. * Willing and able to give informed consent
Exclusion criteria
* No Primary Care Physician * Body weight \>240 kg * Allergy to iodine contrast (only for subjects enrolled in Arm 3) * Creatinine levels \> 1.5 mg/dL or estimated glomerular filtration rate (eGFR) \< 60 ml/minute (only for subjects enrolled in Arm 3) * Recent (1 month) contrast enhanced CT * Any known concomitant acute infection (including upper respiratory infection, genitourinary infections, etc. * History of metastatic or newly (last 5 years) diagnosed locally invasive cancer. * Chemotherapy in the last 5 years * Radiation therapy in the last 3 years * Major surgery within the last 6 months. * Pregnancy or breast-feeding * Diabetes * Fasting blood glucose level \> 160 mg/dL before administration of FDG * Prisoners * The standard MRI contraindications apply, including but not limited to: Having a pacemaker or other implanted electronic device. Metal foreign bodies, aneurysm clips, heart valve prosthesis, vascular stents, cochlear implants, embolization coils, gunshot wounds with retained bullet fragments, penile implant, IUCD. Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | approximatively 6 hours for Arm 1 only | To obtain preliminary data regarding low dose EXPLORER noise level |
| Standardized Uptake Value | approximatively 90 minutes | To collect preliminary data about total body FDG perfusion and early biodistribution. Time-activity curves will be created |
| Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | approximatively 12 hours for Arm 1 only | To collect preliminary data regarding FDG biodistribution in the organs listed as a function of time of 12 hours. Time-activity curves will be created |
| Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | approximatively 3 hours | To obtain preliminary data to understand whether intravenous iodinated contrast agent produce a significant change in quantification of FDG uptake levels. Time/activity curves will be generated. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Delayed Imaging Acquisition 10 mCi of 18F fluorodeoxyglucose (FDG) will be injected through the IV and a 60-minute dynamic scan will begin on EXPLORER. The IV line will be removed after dynamic acquisition. The dynamic scan will be preceded by ultra low-dose (1.298 mSv) CT scan to provide information for attenuation correction for the PET data. At 90 minutes, 3-, 6-, 9- and 12-hours, a static whole-body scan for 20 minutes will be acquired on EXPLORER. Prior to the 90-minute scan a low-dose CT (7.44 mSv) will be obtained both for anatomic localization and for attenuation correction purposes. Prior to each of the later time-points (3-, 6-, 9- and 12-hours), an ultra low-dose (1.298 mSv) CT scan will be acquired. This scan will be for attenuation correction purposes only. Following the 12-hour scan, the participant's study visit will be completed. MRI Brain will be also obtained after PET/CT scanning for anatomic correlation.
EXPLORER PET/CT: Intervention: PET/CT using different protocols | 15 |
| Low FDG Dose Imaging 0.5 mCi of 18F-FDG (1/20th of the standard dose) will be hand injected through the IV and a 60-minute dynamic scan will begin on EXPLORER. The dynamic scan will be preceded by an ultra-low-dose CT scan (1.298 mSv) for attenuation correction. The standard 20-minute EXPLORER scan obtained at 90 minutes will be obtained after a low dose CT (7.44 mSv) for attenuation and co-localization. The standard 20-minute EXPLORER scan obtained at 3 hours will be preceded by an ultra-low-dose CT scan (1.298 mSv) for attenuation correction only. MRI Brain will be also obtained after PET/CT scanning for anatomic correlation.
EXPLORER PET/CT: Intervention: PET/CT using different protocols | 15 |
| Comparison PET Images Reconstructed Using CT-based Attenuation 10 mCi of 18F-FDG will be hand injected through the IV and a 60-minute dynamic scan will begin on EXPLORER. Prior to the dynamic scan, an ultra-low-dose CT scan (1.298 mSv) will be acquired for attenuation correction purposes only. At 90 mins, a low dose non contrast enhancement CT (7.44 mSv) will be acquired vertex to toes. Iodinated contrast (150 cc of iodine Omnipaque 350) will then be intravenously injected (through the same IV placed to inject FDG) at 3 ml/sec while the patient remains still on the scanner and a second low-dose CT will be acquired. Finally, a 20-minute PET acquisition will be performed. The IV line will be removed after completion of the study. MRI Brain will be also obtained after PET/CT scanning for anatomic correlation.
EXPLORER PET/CT: Intervention: PET/CT using different protocols | 0 |
| Total | 30 |
Baseline characteristics
| Characteristic | Delayed Imaging Acquisition | Low FDG Dose Imaging | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 1 Participants | 0 Participants | 1 Participants |
| Age, Categorical Between 18 and 65 years | 14 Participants | 15 Participants | 29 Participants |
| Age, Continuous | 49.5 YEARS | 45.3 YEARS | 47.4 YEARS |
| Ethnicity (NIH/OMB) Hispanic or Latino | 0 Participants | 0 Participants | 0 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 0 Participants | 0 Participants | 0 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 15 Participants | 15 Participants | 30 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants | 1 Participants | 1 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 8 Participants | 4 Participants | 12 Participants |
| Race (NIH/OMB) White | 7 Participants | 10 Participants | 17 Participants |
| Region of Enrollment United States | 15 participants | 15 participants | 30 participants |
| Sex: Female, Male Female | 9 Participants | 7 Participants | 16 Participants |
| Sex: Female, Male Male | 6 Participants | 8 Participants | 14 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk |
|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 15 | 0 / 15 | 0 / 0 |
| other Total, other adverse events | 0 / 15 | 0 / 15 | 0 / 0 |
| serious Total, serious adverse events | 0 / 15 | 0 / 15 | 0 / 0 |
Outcome results
Primary
Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value)
To obtain preliminary data regarding low dose EXPLORER noise level
Time frame: approximatively 6 hours for Arm 1 only
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Aorta | 60.5 coefficient | Standard Deviation 14.8 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Lungs | 140.1 coefficient | Standard Deviation 8.1 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Liver | 32.2 coefficient | Standard Deviation 9 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Spleen | 31.4 coefficient | Standard Deviation 9.3 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Kidneys | 64.4 coefficient | Standard Deviation 18.4 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Bone Marrow | 40.8 coefficient | Standard Deviation 11.8 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Skeletal Muscles | 53.0 coefficient | Standard Deviation 18.8 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Subcutaneous Fat | 88.6 coefficient | Standard Deviation 24.8 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Whole Brain | 54.5 coefficient | Standard Deviation 8.1 |
| Delayed Imaging Acquisition | Coefficient of Variation. SD/Mean (Standard Deviation Divided by Mean Value) | Myocardium | 63.0 coefficient | Standard Deviation 16.7 |
Primary
Standardized Uptake Value
To collect preliminary data about total body FDG perfusion and early biodistribution. Time-activity curves will be created
Time frame: approximatively 90 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Delayed Imaging Acquisition | Standardized Uptake Value | Aorta | 1.75 SUV | Standard Deviation 0.34 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Lungs | 0.62 SUV | Standard Deviation 0.37 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Liver | 2.49 SUV | Standard Deviation 0.44 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Spleen | 2.15 SUV | Standard Deviation 0.4 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Kidneys | 3.65 SUV | Standard Deviation 1.85 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Bone Marrow | 2.51 SUV | Standard Deviation 0.44 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Skeletal Muscles | 0.70 SUV | Standard Deviation 0.19 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Subcutaneous Fat | 0.19 SUV | Standard Deviation 0.05 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Whole Brain | 9.88 SUV | Standard Deviation 2.63 |
| Delayed Imaging Acquisition | Standardized Uptake Value | Myocardium | 10.73 SUV | Standard Deviation 4.92 |
| Arm 2 | Standardized Uptake Value | Subcutaneous Fat | 0.19 SUV | Standard Deviation 0.04 |
| Arm 2 | Standardized Uptake Value | Aorta | 0.88 SUV | Standard Deviation 0.17 |
| Arm 2 | Standardized Uptake Value | Bone Marrow | 0.73 SUV | Standard Deviation 0.15 |
| Arm 2 | Standardized Uptake Value | Lungs | 0.32 SUV | Standard Deviation 0.06 |
| Arm 2 | Standardized Uptake Value | Myocardium | 1.20 SUV | Standard Deviation 0.8 |
| Arm 2 | Standardized Uptake Value | Liver | 1.02 SUV | Standard Deviation 0.19 |
| Arm 2 | Standardized Uptake Value | Skeletal Muscles | 0.37 SUV | Standard Deviation 0.06 |
| Arm 2 | Standardized Uptake Value | Spleen | 0.83 SUV | Standard Deviation 0.15 |
| Arm 2 | Standardized Uptake Value | Whole Brain | 4.95 SUV | Standard Deviation 1.36 |
| Arm 2 | Standardized Uptake Value | Kidneys | 1.45 SUV | Standard Deviation 0.23 |
Primary
Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM
To collect preliminary data regarding FDG biodistribution in the organs listed as a function of time of 12 hours. Time-activity curves will be created
Time frame: approximatively 12 hours for Arm 1 only
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Aorta | 0.83 SUV | Standard Deviation 0.47 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Lungs | 0.48 SUV | Standard Deviation 0.44 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Liver | 1.68 SUV | Standard Deviation 0.51 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Spleen | 2.01 SUV | Standard Deviation 0.49 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Kidneys | 1.91 SUV | Standard Deviation 0.83 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Bone Marrow | 3.44 SUV | Standard Deviation 0.85 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Skeletal Muscles | 1.23 SUV | Standard Deviation 0.44 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Subcutaneous Fat | 0.25 SUV | Standard Deviation 0.21 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Whole Brain | 5.81 SUV | Standard Deviation 1.87 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/ID/BW; C(t) is Radioactivity Measured at the Time t, Decay Corrected to t=0 and Converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; W= Body Weight; SUV is Correct UM | Myocardium | 14.0 SUV | Standard Deviation 6.93 |
Primary
Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM
To obtain preliminary data to understand whether intravenous iodinated contrast agent produce a significant change in quantification of FDG uptake levels. Time/activity curves will be generated.
Time frame: approximatively 3 hours
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Aorta | 1.18 SUV | Standard Deviation 0.3 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Lungs | 0.52 SUV | Standard Deviation 0.53 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Liver | 2.11 SUV | Standard Deviation 0.42 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Spleen | 2.09 SUV | Standard Deviation 0.41 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Kidneys | 3.30 SUV | Standard Deviation 1.34 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Bone Marrow | 2.92 SUV | Standard Deviation 0.56 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Skeletal Muscles | 0.82 SUV | Standard Deviation 0.21 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Subcutaneous Fat | 0.16 SUV | Standard Deviation 0.05 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Whole Brain | 10.39 SUV | Standard Deviation 3.02 |
| Delayed Imaging Acquisition | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Myocardium | 11.60 SUV | Standard Deviation 5.92 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Subcutaneous Fat | 0.07 SUV | Standard Deviation 0.02 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Aorta | 0.39 SUV | Standard Deviation 0.08 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Bone Marrow | 0.44 SUV | Standard Deviation 0.09 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Lungs | 0.15 SUV | Standard Deviation 0.04 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Myocardium | 0.68 SUV | Standard Deviation 0.59 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Liver | 0.50 SUV | Standard Deviation 0.1 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Skeletal Muscles | 0.21 SUV | Standard Deviation 0.04 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Spleen | 0.43 SUV | Standard Deviation 0.08 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Whole Brain | 2.97 SUV | Standard Deviation 0.86 |
| Arm 2 | Standardized Uptake Value SUV(t)= C(t)/(ID/BW); C(t) is Radioactivity Measured From at Time t, Decay Corrected to t=0-converted From a Volume to a Mass Based Unit Via the Factor 1/(1 g/mL); ID: the Injected Dose at t=0; BW= Body Weight; SUV is Correct UM | Kidneys | 0.66 SUV | Standard Deviation 0.12 |