Association Between S-LAAO and Adverse Cardiovascular Events Among Patients Undergoing Coronary Artery Bypass Grafting.

A Chinese Registry to Evaluate the Association of Surgical Left Atrial Appendage Occlusion vs No Receipt of S-LAAO With Adverse Cardiovascular Events Among Petients Undergoing Coronary Artery Bypass Grafting.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04108169

Enrollment

240

Registered

2019-09-30

Start date

2019-10-01

Completion date

2023-01-31

Last updated

2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Surgery

Keywords

Coronary artery bypass graft, Left Atrial Appendage Occlusion, stroke, prevention

Brief summary

This is a prospective, single-center, randomized, active controlled, clinical trail to assess the efficacy and safety of surgical closure of left atrial appendage (LAA) in patients undergoing coronary artery bypass graft.

Interventions

PROCEDURELeft atrial appendage occlusion surgery

CABG according to indications in the current guidelines on myocardial revascularization including surgical closure of left atrial appendage

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Subject undergoing coronary artery bypass grafting according to clinical indications; 2. Age is more than 18 and less than 80 years old; 3. Male and non pregnancy female; 4. Subject understands study requirements and agrees to sign an informed consent from prior to study procedures.

Exclusion criteria

1. Pregnancy female; 2. Participate in other clinical trial in the last 1 month. 3. Subject doesn't agree to sign an informed consent from prior to study procedures. 4. Subject undergoing repeat CABG, concomitant valve or other cardiac surgery. 5. New York Heart Association (NYHA) Class IV heart failure.

Design outcomes

Primary

Measure	Time frame
All-cause death	3 year after discharge (These data is collected during follow-up visit at in-hospital)

Secondary

Measure	Time frame
Composite of ischemic stroke, thromboembolism and all death	3 year after discharge (These data is collected during follow-up visit at in-hospital)
Atrial fibrillation	3 year after discharge (These data is collected during follow-up visit at in-hospital)

Countries

China

Contacts

Primary ContactYulin Li, PHD

lyllyl_1111@163.com86-010-64426153

Backup ContactPing Li, PHD

13520112185@163.com

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026