End Stage Liver DIsease, Liver Transplantation
Conditions
Keywords
endothelial, plasma
Brief summary
To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.
Interventions
BIOLOGICALfresh frozen plasma
perform plasma transfusion in different phases during perioperation
DIAGNOSTIC_TESTblood sample
get blood samples at several specific points in time during perioperation
Sponsors
Beijing Chao Yang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Child A/B cirrhosis * patients who undergo the first OLT * Informed and consented * complete follow-up * cooperate with treatment
Exclusion criteria
* re-transplant * combined liver and other organ transplantation * BMI≥30Kg/m2 * patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion * acute liver failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endothelial glycocalyx layer shedding markers | 24 hours | plasma concentration of endothelial glycocalyx layer shedding markers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| inflammatory cytokines | 24 hours | levels of inflammatory cytokines |
Countries
China
Contacts
Primary ContactXun Liu
Backup ContactAnshi Wu
Outcome results
None listed