Oxytocin Effects on the Prosocial Learning

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04105140

Enrollment

Registered

2019-09-26

Start date

2018-01-01

Completion date

2018-08-10

Last updated

2019-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

oxytocin, prosocial learning

Brief summary

To investigate whether intranasal oxytocin (24 IU) treatment can influence prosocial learning behavior in males.

Detailed description

In a double-blind, within-subject, placebo controlled design, investigators plan to investigate the effect of oxytocin treatment on prosocial learning. Before the self-administration, participants need to finish several questionnaires including IRI, AAS, BASBIS, SPSRQ, SES, PTM, STAI, BDI, ASQ and PNAS. They would finish the PANAS again before the scanning. Participants are informed that they perform the reward learning task either for themselves, another (unknown) person or no one (control). In the probabilistc reward learning task, associations with two stimuli with different reward probabilities are learned via monetary feedback (reward ￥1 or no reward ￥0). After the experiment, participants need to finish the PANAS.

Interventions

DRUGOxytocin

intranasal administration of oxytocin (24 IU)

DRUGPlacebo

intranasal administration of placebo (24 IU)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* without past or current psychiatric or neurological disorders

Exclusion criteria

* history of head injury * medical or psychiatric illness

Design outcomes

Primary

Measure	Time frame	Description
Neural processing during feedback based on prosocial learning assessed by fMRI scanner	1 hour	fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment administrations.

Secondary

Measure	Time frame	Description
Behavioral learning performance measured by E-prime	1 hour	Learning performance will be compared between the treatment administrations by calculating the accuracy of learning.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026