Endothelial Dysfunction, Kidney Disease, Chronic
Conditions
Keywords
chronic kidney disease, dietary nitrates, beetroot juice, endothelium, vascular, cardiovascular disease, exercise capacity
Brief summary
The purpose of this study is to examine the effect of acute ingestion of a concentrated beetroot juice supplement on vascular function and exercise capacity in patients with moderate to severe chronic kidney disease
Detailed description
People with Chronic Kidney Disease (CKD) are at an increased risk of cardiovascular disease. Blood vessel dysfunction and exercise intolerance are common in CKD. Blood vessel dysfunction has been shown to predict future cardiovascular events and decreased physical activity can contribute to an increased risk of cardiovascular disease. Therefore, this study investigates if dietary nitrate from beetroot juice, which has been shown to improve blood vessel function and exercise capacity in other cardiovascular disease pathologies, could be effective at improving these measures in patients with CKD. In a controlled, double blinded trial, stage 3-5 CKD patients will be randomly assigned to receive either beetroot beverage or a placebo and then complete measures of blood vessel function and an exercise test.
Interventions
DIETARY_SUPPLEMENTBeet It Sport Shot
Source of naturally occurring dietary nitrates
DIETARY_SUPPLEMENTNitrate-depleted placebo
Placebo
Sponsors
University of Delaware
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Stage 3-5 Chronic Kidney Disease
Exclusion criteria
* History of cardiovascular disease * Current pregnancy * Uncontrolled hypertension * Uncontrolled hyperlipidemia * Current hormone replacement therapy * Current use of tobacco products * Current autoimmune disease * Current hyperkalemia * Diagnosis of a deep vein thrombosis (DVT) within the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular Function, assessed by laser Doppler flowmetry coupled with intradermal microdialysis | 2.5 hours post ingestion of juice | Nitric oxide mediated cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with microdialysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial function | 2.5 hours post ingestion of juice | Conduit artery endothelial function assessed by brachial artery flow mediated dilation |
| Blood pressure | Change from pre-ingestion baseline to 2.5 hours post ingestion of juice | Blood pressure recorded by automatic blood pressure machine |
| Arterial stiffness | 2.5 hours post ingestion of juice | Carotid to femoral pulse wave velocity assessed by tonometry |
| Pulse wave analysis | 2.5 hours post ingestion of juice | Central blood pressure and augmentation index assessed by oscillometry and radial tonometry |
| Peak aerobic capacity | 2.5 hours post ingestion of juice | Peak oxygen uptake (VO2 peak) during incremental cycling exercise to exhaustion |
Countries
United States
Outcome results
None listed