Amnestic Mild Cognitive Impairment, Cognitive Function, Executive Function, Interactive Stepping Exercise, Memory
Conditions
Keywords
square stepping exercise, Amnestic mild cognitive impairment, Interactive stepping exercise, memory, cognitive function, executive function
Brief summary
This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly assigned to either the ISE group or control group. The ISE intervention conducts three times a week for 16 weeks. Outcomes are measured at baseline and after intervention. The primary outcomes are the Chinese version verbal learning test (CVVLT), selective reminding test (SRT), and logic memory test (Wechsler Memory Scale). The secondary outcomes are Montreal Cognitive Assessment (MoCA) for cognitive function, and trail making test Part A & B (TMT-A & B), Stroop test, and 25-item Executive Interview (C-EXIT 25) for executive function.
Interventions
An exercise intervention based on the principle of square stepping exercise
OTHERHome exercise
Home exercise
Sponsors
National Yang Ming Chiao Tung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Age≥50 years * Complained of memory impairment * Chinese Version Verbal Learning Test 10-minute delays ≤ 6 words * MMSE score≥24 and CDR score=0.5 * Activities of daily living are intact * DSM-IV criteria for the diagnosis of dementia is not met
Exclusion criteria
* Any significant neurologic disease other than suspected incipient Alzheimer's disease * Psychotic features, contraindication of exercise... which could lead to difficulty complying with the protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Logic memory test | Change from baseline at 12 week |
| Chinese version verbal learning test | Change from baseline at 12 week |
| Selective reminding test | Change from baseline at 12 week |
| Wechsler Memory Scale-III | Change from baseline at 12 week |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment | Change from baseline at 12 week |
| Trail making test | Change from baseline at 12 week |
| Stroop test | Change from baseline at 12 week |
| Executive Interview | Change from baseline at 12 week |
Contacts
Primary ContactYea-Ru Yang
Outcome results
None listed