Insulin Resistance, Metabolic Disease, Mitochondrial Metabolism, Overweight and Obesity, Sedentary Lifestyle
Conditions
Brief summary
Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.
Interventions
BEHAVIORALShort-term Exercise Training
Participants will perform 2-weeks of supervised exercise training on a stationary bike.
Sponsors
Oregon State University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Participants will be asked to complete 2 screening visits to determine eligibility. If participants remain eligible, they will be asked to complete 2 metabolic study visits, 1 before and 1 after 2 weeks of supervised exercise training on a stationary bike.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-45 years * Body mass index (BMI) 18-45 kg/m2 * Sedentary (\<1 hour of planned exercise per week)
Exclusion criteria
* Regular exercise (\>1 hour of planned exercise per week) * Smoking, tobacco or nicotine use within the last 1-year * Fasting glucose \>126mg/dL * Hypertension (systolic pressure \>140 mmHg or diastolic pressure \>90 mmHg) * Chronic metabolic or cardiovascular health conditions * Pregnant, nursing, irregular menses or post-menopausal * Lidocaine allergy * Certain medications * Physical limitations that prevent safe or successful exercise completion * Diminished capacity for consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in skeletal muscle mitochondrial protein degradation peptide products | After 2-weeks of exercise training compared with before training. | Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training. |
Countries
United States
Outcome results
None listed