Exercise Activity, Hypertension,Essential
Conditions
Brief summary
The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.
Interventions
OTHER24h-Ambulatory Blood Pressure
Effect of High Intensity Interval Training compared to Hydrochlorothiazide on ambulatory Blood Pressure.
Sponsors
Anil Nigam
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Age at consent ≥ 60 years; 2. Systolic Blood pressure measured through BPtru™ between SBP ≥ 120 mmHg and \< 140 and or DBP ≥ 80 mmHg 3. Being able to sign the informed consent form
Exclusion criteria
1. Considered highly active according to the International Physical Activity Questionnaire 2. Practicing more than 20 min per week of High-Intensity Interval Training 3. Use of antihypertensive medication 4. Contraindication for the practice of intense physical activity 5. Functional limitations related to the exercise test and to intensive training 6. Cardiovascular pathology 7. Atrial fibrillation 8. Psychiatric or neurological disorder 9. Renal failure 10. MMSE score \< 26 11. Persons benefiting of enhanced protection: persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and patients in emergency situations. 12. Diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 24h-Ambulatory Blood Pressure | At baseline and after twelve weeks of intervention | The 24-hour ambulatory measure of the blood pressure (AMBP) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Flow Mediated Dilatation (FMD) | Before and after twelve weeks of intervention | Percentage of dilatation of the brachial artery |
| Cardiovascular evaluation | Before and after twelve weeks of intervention | Maximum incremental cardiopulmonary exercise test (VO2MAX) |
| Cognitive functions | Before and after twelve weeks of intervention | Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. The investigators will measure change of score to the cognitive tests. |
Countries
Canada
Contacts
Primary ContactAnil Nigam, MD
Backup ContactAntoine Langeard, PhD
Outcome results
None listed