Multiparametric Imaging for Analysis of MVNT (Multinodular and Vacuolating Neuronal Tumor)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04103190

Acronym

MIAM

Enrollment

Registered

2019-09-25

Start date

2019-12-10

Completion date

2025-07-10

Last updated

2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Benign Neuronal Desease

Brief summary

Differential diagnoses of MVNT include DNT (dysembryoplastic neuroepithelial tumor), low-grade gliomas, cortical dysplasias or even hamartomas.

Detailed description

Differential diagnoses of MVNT include DNT (dysembryoplastic neuroepithelial tumor), low-grade gliomas, cortical dysplasias or even hamartomas. However, in order to avoid an invasive surgical procedure to remove the lesion, a certain diagnosis of its benignity is essential. The contribution of advanced techniques in MRI, such as spectroscopy in the characterization of these lesions, has not yet been studied today

Interventions

DEVICEcerebral MRI

Patients who agree to participate in the study will perform a 3T multi-parametric MRI with advanced spectroscopic imaging techniques and standard protocol. A neurological consultation will take place during the inclusion visit as well as a questionnaire and a control MRI at 1 year and 2 years +/- 1 month.

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient over 18 years old * Suspicion of MVNT on an MRI: it is considered that it will be necessary at least the 2 major criteria associated with at least 1 minor criterion to enter the definition of suspicion of MVNT: Major criteria: * Multinodular aspect in cluster * High FLAIR hypersignal / T2 Minor criteria: * Absence of mass effect * Hyposignal T1 * Center of the lesion in hypsignal FLAIR or T1 hypersignal * Affiliate or beneficiary of a Social Security scheme * Having received informed information about the study and consenting to participate in the study

Exclusion criteria

* Patient benefiting from a legal protection measure * Pregnant or lactating woman * Contraindication to MRI

Design outcomes

Primary

Measure	Time frame	Description
Description of a new radiological entity on Spectroscopy : the MVNT (Multinodular and Vacuolating Neuronal Tumor)	1 day	ratio of N-Acetylaspartate / Choline on Spectroscopy
Description of a new radiological entity on Spectroscopy : : the MVNT (Multinodular and Vacuolating Neuronal Tumor)	1 day	area under curve of choline Spectroscopie

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026