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Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography

Effect of Residual Myocardial Ischemia on Recovery of Left Ventricular Function After Primary Percutaneous Coronary Intervention

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04103008
Enrollment
100
Registered
2019-09-25
Start date
2019-11-01
Completion date
2020-12-01
Last updated
2019-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Echocardiography 2D, Left Ventricular Dysfunction, Myocardial Infarction

Keywords

Speckle tracking, 2D echocardiography, Left ventricle residual function, PCI, percutaneous coronary intervention, single coronary artery, multiple coronary arteries

Brief summary

Recovery of the left ventricular function is variable from one patient to another, thus assessment of cardiac function by measuring left ventricular ejection fraction using echocardiography is the most common in the daily clinical practice. However, this technique has limitation related with its intra- and interobserver variability. A recent technique, 2D speckle tracking for assessing global longitudinal strain, has been introduced to reduce the variability and potentially has a higher accuracy. Speckle tracking is a method which uses two dimensions recording for measuring quantity of movement of myocardium in several segments. Speckle-tracking echocardiography is a current noninvasive ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function independently from the angle of insonation and from cardiac translational movements,

Detailed description

Authors using 2D speckle tracking found that subclinical LV systolic dysfunction is common in patients with isolated severe mitral stenosis (MS) and is determined primarily by the hemodynamic variables of MS severity and reduced LV filling. BMV results in rapid recovery of LV systolic function in these patients through improvement in LV diastolic loading. These findings suggest that LV contractile properties in MS are modulated predominantly by LV diastolic filling rather than myocardial structural abnormality.

Interventions

assess left ventricular function on admission and after 40 days

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years

Inclusion criteria

* Patients with acute myocardial infarction eligible for PCI seen on admission and after 40 days

Exclusion criteria

* cardiomyopathy * cancer * on cytostatic treatment.

Design outcomes

Primary

MeasureTime frameDescription
Assessing change of left ventricular functionbaseline and after 40 days of PCImeasure ejection fraction

Secondary

MeasureTime frameDescription
Major adverse cardiovascular events40 daysnon fatal myocardial infarction, non fatal stroke, CV death

Countries

Egypt

Contacts

Primary ContactKarim ME Aly
karimeltaher294@gmail.com01068545195
Backup ContactAliae AR Mohamed-Hussein, MD
aliaehussein@gmail.com01222302352

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 8, 2026