Gut Microbiome
Conditions
Brief summary
The purpose of this research study is to determine whether consuming snacks containing different blends of dietary fibers alters the type and number of bacteria found in your gut and improves markers of overall health.
Detailed description
All subjects will complete a 47-day, multi-phase feeding study to evaluate the effect of two snack prototypes containing two different fiber blends on gut community structure and features of host biological state (plasma proteome/ metabolome). The information gained from this work will increase our understanding of the importance of specific dietary fibers in manipulating the composition of the gut microbiota in ways that may improve our metabolic health.
Interventions
OTHERTwo fiber-blend snack and four fiber-blend snack
All subjects will complete a 47-day, multi-phase feeding study to evaluate the effect of two snack prototypes containing two different fiber blends on gut community structure and features of host biological state (plasma proteome/ metabolome).
Sponsors
Washington University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI ≥25.0 and ≤35.0 kg/m2 * ≥18 and ≤60 years
Exclusion criteria
* previous bariatric surgery * significant organ system dysfunction (e.g., diabetes, severe pulmonary, kidney, liver or cardiovascular disease) * cancer or cancer that has been in remission for \<5 years * major psychiatric illness * inflammatory gastrointestinal disease * pregnant or lactating women * use of medications that are known to affect the study outcome measures and that cannot be temporarily discontinued for this study * use of medications known to affect the composition of the gut microbiota within the last 30 days (most notably antibiotics) * bowel movements \<3 times per week * vegans, vegetarians, those with lactose intolerance and/or severe allergies/aversions/sensitivities to foods and ingredients included in the prescribed meal plan * persons who are not able to grant voluntary informed consent * persons who are unable or unwilling to follow the study protocol or who, for any reason, the research team considers not an appropriate candidate for this study, including non-compliance with screening appointments or study visits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of fiber blend snacks on gut microbiota | 1 year | Stool samples will be analyzed to determine changes in type and number of gut microbiota. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of fiber blend snacks in blood and urine | 1 year | Blood and urine samples will be analyzed to assess how many proteins and metabolites are present in these samples before and after fiber snack supplementation. |
Countries
United States
Outcome results
None listed