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Conditions
Keywords
Microbiome
Brief summary
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Alzheimer's disease.
Detailed description
The goal of this Research Study is to better understand how the genetic information in subject's microbiome correlates to the information provided in surveys and in medical records regarding Alzheimer's disease.
Interventions
OTHERNo Intervention
There is no intervention for this study.
Sponsors
ProgenaBiome
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study 2. Male or female patients age 18 and older 3. Diagnosis of Alzheimer's disease or dementia by a physician 4. Mini Mental Status Exam score less than 26
Exclusion criteria
1. Refusal to sign informed consent form 2. Treatment with antibiotics within 2 weeks prior to screening 3. Treatment with probiotics within 2 weeks prior to screening 4. History of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy. 5. Postoperative stoma, ostomy, or ileoanal pouch 6. Participation in any experimental drug protocol within the past 12 weeks 7. Treatment with total parenteral nutrition 8. Any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial 9. Inability to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of Microbiome to Alzheimer's Disease via Relative Abundance Found in Microbiome Sequencing | 1 year | Relative abundance of bacterial classes within taxonomic phyla and, more broadly, within their domain will be analyzed by sequencing the gut microbiome. These data will then be correlated to Alzheimer's disease state |
Countries
United States
Outcome results
None listed