Intervention for Employed Women With Multiple Sclerosis

Neuropsychological Feedback Style and Case Management to Improve Intervention Outcome for Employed Women With Multiple Sclerosis: a Randomized Clinical Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04100525

Enrollment

Registered

2019-09-24

Start date

2016-04-30

Completion date

2022-01-31

Last updated

2021-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Employment, Vocational Rehabilitation

Brief summary

Unemployment is particularly common among women with multiple sclerosis (MS). This study uses a vocational rehabilitation program involving neuropsychological testing as an intervention. The use of in-person feedback and case management following neuropsychological testing is compared to phone feedback only. Adherence to treatment and employment outcomes will be evaluated over three years.

Detailed description

Employed women at a tertiary-care MS center were screened for common issues impacting work productivity (fatigue, cognitive dysfunction, and depression). Women who met screening criteria were randomized to one of two treatment groups: either neuropsychological testing and phone feedback to review findings and tailored recommendations (standard-care treatment); or neuropsychological testing, in-person feedback, and two calls from a care-coordinator (experimental treatment). Adherence to recommendations and employment status at one year are evaluated. Follow-up periods also occur at year two and year three.

Interventions

BEHAVIORALNeuropsychological testing intervention plus follow up

Neuropsychological testing for women experiencing significant fatigue, mood, or cognitive symptoms. Feedback type and case management services varied depending on randomized group.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Masking description

Participants were informed that they would receive feedback but were not told whether it would be in person or by phone until after randomization. Participants were not informed that only one group received case management calls.

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 64 Years

Healthy volunteers

Yes

Inclusion criteria

* Female sex * Age between 18 and 64 * Employed at least 20 hours per week * Confirmed diagnosis of MS

Exclusion criteria

* Experiencing an MS exacerbation * Endorsing suicidal ideation or intent * Pregnant * Severe psychiatric disorder * History of traumatic brain injury * Dementia * Major neurological illness other than MS

Design outcomes

Primary

Measure	Time frame	Description
Employment	Approximately 12 months	Has there been a decrease in employment status (Yes/No)

Secondary

Measure	Time frame	Description
Adherence to Recommendations	Approximately 12 months	Percentage of recommendations completed at one year

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026