Overweight and Obesity
Conditions
Keywords
Low-carbohydrate-high-fat diet (LCHF), Low-density-lipoprotein (LDL), High-density-lipoprotein (HDL), Triglycerides (TG), Lipids, Glucose tolerance (GT), Insulin resistance (IR), Body composition, Weight
Brief summary
The study evaluates the effect of exercise and/or diet during on body weight, body composition and health related blood parameters. Participants are overweight sedentary females, allocated to four different groups: Normal diet, Low-carb-high-fat diet, Normal diet + exercise, Low-carb-high-fat diet + exercise.
Detailed description
Diet and exercise can both be efficient tools to reduce bodyweight, get healthier body composition and improve many different health related blood parameters such as cholesterol and glucose tolerance. Exercise has superior effect on skeletal muscle in the context of glucose tolerance, but adherence to exercise program can be a huge challenge for overweight individuals. While exercise has profound effect on metabolic health, diet has been superior when it comes to weight reduction. Previous studies have shown that 5-7% weight loss can improve glucose tolerance, measured as reduced fasting glucose and reduced 2-hour post prandial glucose. We wish to see if the combination exercise and diet is superior to diet only when it comes to over all health.
Interventions
OTHERExercise
Exercise program - indoor bicycle interval exercise, duration 60 min 3x week
OTHERNormal Diet
Normal diet recommended by the health authorities
OTHERLCHF Diet
LCHF Diet, a modified Atkins diet with high percentage of fat and very low percentage of karbohydrates
Sponsors
Norwegian School of Sport Sciences
Atlantis Medical University College
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Diet and exercise, or diet only
Eligibility
Sex/Gender
FEMALE
Age
33 Years to 47 Years
Healthy volunteers
No
Inclusion criteria
* Women * Sedentary * Premenopausal * Caucasian * BMI 26.9 - 36.1 * Age 33-4 * Living close to, or in Oslo.
Exclusion criteria
* Pregnancy * Breast-feeding * Smoking or tobacco use * Previous medical history of cardio-vascular disease (CVD) * Previous medical history of diabetes * Previous medical history of endocrine disorder * Previous medical history of kidney disease * Use of lipid lowering medication * Use of diabetes medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Area under curve (AUC) glucose | Change from baseline AUC glucose at 10 weeks | AUC glucose measured during an OGTT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lipid profile | Change from Baseline lipids at 10 weeks | Measurements of total cholesterol, LDL, HDL, TG |
| Body composition | Change from baseline values at 10 weeks | Measurement of lean body mass, fat free mass, fat mass, visceral fat, bone mass |
| Cardiorespiratory fitness | Change from baseline values at 10 weeks | Measurement of peak oxygen uptake |
Countries
Norway
Outcome results
None listed