Infections With CPB
Conditions
Keywords
Carbapenemase-producing Klebsiella pneumoniae, antibiotic resistancy, infections with Carbapenemase-producing Bacteria (CPB), Carbapenemase-producing Bacteria
Brief summary
This retrospective and prospective study is to investigate the incidence of Carbapenemase-producing bacteria (CPB) at the University Hospital Basel, the time to detection of CPB and to initiation of infection control measures, the risk factors associated with carriage of CPB, type and duration of previously administrated antibiotic medication, antibiotic treatment, as well as to assess the outcomes of the affected patients.
Interventions
OTHERdata collection for demographic data
data collection for demographic data (age, gender, hospital admission and discharge date, length of stay, hospitalization prior to current hospital stay (acute care facilities, long-term healthcare centres, nursing homes), discharge destination, outcome, cause of death, travel history, previous exposure to antibiotics and proton pump Inhibitors)
OTHERdata collection for clinical data
data collection for clinical data (comorbidities, Charlson Comorbidity Index, immunosuppressive treatment, date of diagnosis of CPB, days between hospital admission and diagnosis of CPB, type of consecutive infection, indwelling vascular hardware, urinary catheterization, surgical therapies)
OTHERdata collection for treatment data
data collection for treatment data (antibiotic therapy, immunosuppressive therapy, concomitant medication)
OTHERdata collection for microbiological data
data collection for microbiological data (species of CPB, type of sample, date of sample, history of colonization or infection with any antibiotic resistant pathogen)
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with detection of carbapenemase-producing bacteria from January 1st , 2008 until December 31st , 2028
Exclusion criteria
* Patients with documented refusal of subsequent use of their data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of CPB at the University Hospital Basel (number) | from January 1st , 2008 until December 31st, 2028 | incidence of CPB at the University Hospital Basel (number) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to detection of CPB (days) | from January 1st , 2008 until December 31st, 2028 | time to detection of CPB (days) |
| time to initiation of infection control measures | from January 1st , 2008 until December 31st, 2028 | time to initiation of infection control measures |
| time to adequate treatment in patients with CPB infections | from January 1st , 2008 until December 31st, 2028 | time to adequate treatment in patients with CPB infections |
| presence of established risk factors for CPB | from January 1st , 2008 until December 31st, 2028 | presence of established risk factors for CPB |
| length of hospital stay (days) | from January 1st , 2008 until December 31st, 2028 | length of hospital stay (days) |
| discharge destination | from January 1st , 2008 until December 31st, 2028 | discharge destination |
| cure from infection | from January 1st , 2008 until December 31st, 2028 | cure from infection |
| cause-specific mortality (number) | from January 1st , 2008 until December 31st, 2028 | cause-specific mortality (number) |
| all-cause mortality (number) | from January 1st , 2008 until December 31st, 2028 | all-cause mortality (number) |
Countries
Switzerland
Contacts
CONTACTSarah Tschudin Sutter, Prof. Dr. MD
CONTACTIsabelle Vock, Dipl. med
PRINCIPAL_INVESTIGATORSarah Tschudin Sutter, Prof. Dr. MD
University Hospital Basel, Division of Infectious Diseases and Hospital Epidemiology
Outcome results
None listed