Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases

Prevalence of Right Ventricular Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases and Its Impact on Outcomes

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04098094

Acronym

DVD

Enrollment

Registered

2019-09-23

Start date

2019-09-19

Completion date

2022-10-30

Last updated

2022-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Exacerbation of Asthma, Acute Exacerbation of Bronchiectasis, Acute Exacerbation of COPD, Acute Respiratory Failure, Interstitial Lung Disease, Neuromuscular Diseases, Obesity Hypoventilation Syndrome

Brief summary

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure. The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Detailed description

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure. Inclusion Criteria: * Chronic respiratory disease (COPD, ILD, OHS...) * Admission in ICU for acute respiratory failure * Patient's non-opposition Exclusion Criteria: * Patients \< 18 year-old * Protected patients * Pregnant women The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Chronic respiratory disease (COPD, ILD, OHS...) * Admission in ICU for acute respiratory failure * Patient's non-opposition

Exclusion criteria

* Patients \< 18 year-old * Protected patients * Pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Survival	Day 28	Survival at day 28

Secondary

Measure	Time frame	Description
Duration of ventilation	Day 28	Duration of non-invasive ventilation and/or mechanical ventilation

Other

Measure	Time frame	Description
Duration of hospital stay	Day 28	Duration of hospital stay

Countries

France

Contacts

Primary ContactAthénaïs Boucly, MD

athenais.boucly@gmail.com+33669286528

Backup ContactAthénaïs Boucly, MD

athenais.boucly@gmail.com

Outcome results