Osteoradionecrosis of Jaw
Conditions
Brief summary
osteoradionecrosis (ORN) affects up to 30% of irradiated patients and can occur up to several decades after stopping treatment. Differents therapeutics exist but there is no consensus concerning the management of the maxillary ORN. The understanding of new pathological mechanisms opens the way to new therapeutic perspectives.
Interventions
DRUGPentoxifylline-Tocopherol-Clodronate
the aim of this retrospective study is to analyze from patient records the impact of the PENTOCLO protocol on maxillofacial osteoradionecrosis at Brest Hospital University, France.
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient over 18 being or having been treated by pentoclo combination for an osteoradionecrosis of the jaw
Exclusion criteria
* Tumoral recidivism * Precocious stop of pentoclo
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical evolution of the osteoradionecrosis lesion after introducing PENTOCLO protocol | 2 years | Retrospective study based on recovering patient data from medical records |
Countries
France
Outcome results
None listed