Thyroid Eye Disease
Conditions
Brief summary
Thyroid associated ophthalmopathy (TAO) is a common autoimmune disorder. The pathogenesis of TAO is unclear, and studies found that T cell, B cell and monocytes, macrophages and mast cells are located in the orbital tissue of TAO. Dysthyroid optic neuropathy (DON) is the most serious complication of TAO, which can cause blurred vision, color vision and vision function damage, and affects the quality of life. Investigation of the therapeutic effect of orbital decompression may provide some clues to make the policy at treatment of DON. We explore the therapeutic effect of orbital decompression in patients with DON in both eyes.
Interventions
PROCEDUREOrbital decompression combined with MPT
Orbital decompression combined with MPT
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
\- Ability to perform visual fields and VEP examination Without any serious systemic diseases Without any surgery on eyes in six months
Exclusion criteria
\- With any serious systemic diseases With any surgery on eyes in six months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IOP | 6 months | intraocular pressure in mmHg |
| upper eyelid retraction | 6 months | upper eyelid retraction in mm |
| CAS | 6 months | clinical activity score |
| BCVA | 6 months | best corrected visual acuity in logMAR |
| proptosis | 6 months | proptosis in mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MD | 6 months | mean deviation of visual field in dB |
| PSD | 6 months | pattern standard deviation of visual field in dB |
Countries
China
Outcome results
None listed