Evaluation of Lung Volume Under Nasal High Flow With a Time of Flight Camera

Healthy Volunteers, High Flow Nasal, Lung Volume, Time of Flight Camera

The effectiveness of Nasal High Flow therapy (NHF), in comparison with conventional oxygen therapy, is based on Positive Expiratory Pressure (PEP) and washout of dead space. Many authors have shown that peak expiratory pressure, expiratory plateau pressure, mean upper airway pressure and lung volume were significantly increased. It depends mainly on gas flow and mouth closure. First, Grovesshowed in 2007 that mouth opening could vary nasopharyngeal pressure from 2.7 to 7.4 cmH20 to 60 L / min, like Parke did in 2009, with a pressure of 1.2 at 2.7 cmH2O at 35 L / min. Then, Parke showed in 2011 and 2015, a nasopharyngeal pressure changing from 2.7 to 11.9 cmH20 by varying the flow rate from 30 to 100 L / min. Bräunlich also showed concordant results in 2018, from 1.6 to 2.3 cmH2O, changing flow rates from 20 to 40 L / min. Corley in 2011 found a pressure from -0.3 to 2.7 by passing from ambient air to high flow. Okuda and Mauri's work in 2017 on oesophageal pressures also contributed to this. In addition, it has been proved that the Tidal Volume (TV) is proportional to the flow delivered. These measurements were carried out by impedancemetry, the results of which were extrapolated to Vt. Thus Okuda evaluated it at 685mL in ambient air and 968mL at 50L / min. In 2016, Fraser highlighted a TV increasing from 400 to 500 mL by increasing the flow rate to 30 L / min. Parke in 2015 described an exponential End Expiratory Lung Impedence (EELI) proportional to the flow rate, as did Riera in 2013 with a ratio of 1.26 between ambient air and NHF at 40 L / min, and Corley in 2011 (ratio of 1.25). Actualy, Time-of-Flight (ToF) cameras, such as Kinect v2®, are increasingly used in the medical field, particularly to characterize respiratory movement. Various authors have shown a good correlation between the values of TV obtained by spirometry (reference method) and those obtained with ToF camera. A study led in 2018, by S. Nazir in the Department of Réanimation Médicale at the University Hospital of Brest, evaluated the average errors less than 46mL, with 76% of measurements having an error less than 50 mL, which corresponds to the clinical limit. Now having a non-invasive, safe, simple, reproducible, inexpensive, and allowing evaluation in clinical situations method ; the use of a Time-of-Flight camera to evaluate the breathing and its various parameters, is indicated. In this innovative study, never performed in different respiratory conditions in vigilant patients with NHF, the lung volume will be evaluated by a Time-of-Flight camera. Different clinical situations, and the different parameters influencing it, will be observed and compared with the results of previous studies. These situations will be simulations ranging from a physiological state to an acute respiratory distress.

France