Neonatal SEPSIS
Conditions
Keywords
lactoferrin
Brief summary
Oral lactoferrin versus Placebo will be given to preterm neonates
Detailed description
200 patient were included in the study , one hundred received oral placebo in the form of 2 ml saline , the other 100 preterm neonates received oral lactoferrin with monitoring of C-reactive protein , different cultures, complete blood count on day 7 and after one month.
Interventions
DRUGLactoferrin
lactoferrin is given orally in comparsion to placebp
DRUGPlacebos
placebp is given in 2 ml saline
Sponsors
Kasr El Aini Hospital
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Masking description
Follow up of the patients with CRP and different cultures.
Intervention model description
placebo group 100 patient will receive 2 ml saline for one month in comparison with oral lactoferrin for the same period to another 100 patient
Eligibility
Sex/Gender
ALL
Age
1 Days to 7 Days
Healthy volunteers
Yes
Inclusion criteria
All neonates born at Cairo university hospital NICU
Exclusion criteria
* Neonatal deaths before 3 days postnatal . * Neonates with underlying gastrointestinal problems that prevent oral intake. * Neonates with major congenital anomalies . * Neonates with severe hypoxic ischemic encephaloapathy . * Neonates whose parents refuse to participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in mortality rate of neonatal sepsis in preterm neonate | one year | Neonates will be assessed by C-reactive protein and different cultures to identify Neonatal sepsis |
| Number of Preterm Neonates who will have long term Complication after one month of regular use of Lactoferrin | one year | Neonates will be assessed for long term complication as necrotizing enterocolitis , retinoapathy of prematurity and bronchopulmonary dysplasia |
Countries
Egypt
Outcome results
None listed