Hypertension, Obesity
Conditions
Brief summary
The study aims to investigate the characteristics of subjects with hypertension at onset among a cohort of apparently healthy subjects, with overweight or obesity (BMI ≥ 25 Kg / m2), and free of any drug treatment at the baseline. The evaluation includes anthropometric (weight, height, BMI, waist circumference), haematochemical (hormones, metabolic and routine) parameters and the screening for hypertension with ABPM. The diagnosis of hypertension is made in accordance with the 2017 guidelines of the American College of Cardiology / American Heart Association ACC / AHA.
Interventions
OTHERObservational study
Observational and prospective study
Sponsors
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Overweight or obesity (BMI\> 25 Kg/m2)
Exclusion criteria
* Any kind of drug * Hypertension * Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), * Chronic inflammatory diseases * Renal failure * Liver failure * Angina pectoris * Myocardial infarction and heart failure * Genetic heart diseases * Thrombocytopenias
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total cholesterol | At baseline | Total cholesterol (mg/dL) concentrations in serum |
| eGFR (estimated glomerular filtration rate) | At baseline | eGFR (ml/min/1.73 mq) |
| Creatinin | At baseline | Creatinin (mg/dl) concentration in serum |
| Uric acid | At baseline | Uric acid (mg/dL) concentration in serum |
| Thyroid hormones (FT3, FT4) | At baseline | FT3 (pg/mL), FT4 (pg/mL) concentration in serum |
| HDL cholesterol | At baseline | HDL cholesterol (mg/dL) concentrations in serum |
| LDL cholesterol | At baseline | LDL cholesterol (mg/dL) concentrations in serum |
| Triglycerides | At baseline | Triglycerides (mg/dL) concentrations in serum |
| TSH | At baseline | TSH (mU/L) concentration in serum |
| Insulin | At baseline | Insulin (mIU/L) concentration in serum |
| Potassium | At baseline | Potassium (mmol/L) concentration in serum |
| Sodium | At baseline | Sodium (mEq/L) concentration in serum |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Height | At baseline | Height in meters |
| Weight | At baseline | Weight in kilograms |
| BMI | At baseline | BMI (kg/m\^2) |
Countries
Italy
Outcome results
None listed