Congenital Heart Disease
Conditions
Brief summary
Congenital heart disease is the most common congenital malformation in the world with high morbidity and mortality. However, there is no data to assess the perioperative outcome of congenital heart disease surgery among Chinese cross-regional population. This study aims to investigate the perioperative outcome of congenital heart disease surgery in childhood from a chinese cross-regional cohort.
Interventions
PROCEDURECongenital Heart Disease Surgery
Patients with congenital heart disease will undergo congenital heart disease surgery.
Sponsors
Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Weeks to 18 Years
Healthy volunteers
No
Inclusion criteria
* Subject was aged 1 week-18 years * Subjects underwent congenital heart disease surgery; * Available data to investigate perioperative outcome.
Exclusion criteria
* Cardiac reoperation; * Emergency surgery; * Interventional procedure within prior 30 days prior to surgery; * Missing outcome data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of systemic inflammatory response syndrome | postoperative day 7 or hospital discharge, whichever occurred first. | Systemic inflammatory response syndrome was determined mainly on (i) Core temperature of \>38.5°C or \<36°C measured by rectal, oral, or central catheter probe; (ii) Tachycardia, defined as a mean heart rate \>2 SD above normal for age in the absence of external stimulus, chronic drugs, or painful stimuli; or otherwise unexplained persistent elevation over a 0.5- to 4-hr time period, or for children \<1 yr old: bradycardia, defined as a mean heart rate \<10th percentile for age in the absence of external vagal stimulus; or otherwise unexplained persistent depression over a 0.5-hr time period; (iii) Mean respiratory rate \>2 SD above normal for age, the prolonged mechanical ventilation defined as ventilation duration \> 48 hrs, or unplanned re-intubation for an acute process not related to underlying neuromuscular disease or the receipt of general anesthesia; (iv) Leukocyte count elevated or depressed for age or \>10% immature neutrophils. |
Countries
China
Contacts
Primary ContactHong Liu, MD
Outcome results
None listed