Dentinal Hypersensitivity
Conditions
Keywords
Biorepair sensitive toothpaste, Clinical trial, Dentinal Hypersensitivity, Schiff Sensitivity Scale, Zinc-carbonate hydroxyapatite nanocrystals
Brief summary
The purpose of this clinical study is to evaluate the effect of desensitizing toothpaste containing zinc-carbonate hydroxyapatite nanocrystals in reducing or controlling DH after 8 weeks of treatment
Detailed description
This clinical study design is an 8-week single center, before and after use of desensitize dentifrice. This study will conducted in the College of Dentistry Qassim University. 72 patients surfing from DH, include in the study fulfill the inclusion criteria. All subjects 20 to 70 years of age in good health, and must have 2 teeth with DH, will be included in this study. Screening will be performed for the selection of patients, which fulfill the inclusion criteria. Baseline data will be recorded and Sensitivity was assessed by air-blast sensitivity, using Schiff Sensitivity Scale (SSS). Sensitivity was assessed by air-blast sensitivity, using Schiff Sensitivity Scale (SSS) described as follows. 0 = Subject does not respond to air stimulus 1. = Subject responds to air stimulus but does not request discontinuation of stimulus 2. = Subject responds to air stimulus and requests discontinuation or moves from stimulus 3. = Subject responds to air stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus
Interventions
OTHERSingle arm clinical study
Participants will be treated with desensitizing toothpaste containing zinc-carbonate hydroxyapatite nanocrystals (Zn-CHA) for 8 weeks.
Sponsors
Qassim University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Clinical trials with a single arm: Participants will be treated with desensitizing toothpaste containing zinc-carbonate hydroxyapatite nanocrystals (Zn-CHA) for 8 weeks.
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* All male and female subjects 20 to 70 years of age * All subjects in good health * All subjects must have 2 teeth with DH, only incisors, canine and premolars were included with the exposed cervical dentin (facial surfaces). All participants of the study having Schiff Sensitivity Scale score of 2 & 3
Exclusion criteria
* Subjects with deep carious teeth, defective restorations * Any pathological lesion * Periodontal disease, mobile teeth, cracked enamel, orthodontic appliances, * Periodontal pockets \>4mm * Subjects using pain control medicines, sensitive toothpaste * Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dentine hypersensitivity (DH) evaluation by means of air-blast sensitivity test, using Schiff Sensitivity Scale (SSS) after 4 weeks. | 4 Weeks | This will be assessed using Schiff Sensitivity Scale (SSS) score difference from the baseline, that will be determined immediately before product use and then after 4 weeks of daily brushing with the test sensitive toothpaste. Tooth sensitivity score was assessed by air-blast sensitivity, using Schiff Sensitivity Scale (SSS) as follows: 0 = Subject does not respond to air stimulus, 1 = Subject responds to air stimulus but does not request discontinuation of stimulus, 2 = Subject responds to air stimulus and requests discontinuation or moves from stimulus, 3 = Subject responds to air stimulus, considers stimulus to be painful, and requests. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dentine hypersensitivity (DH) evaluation by means of air-blast sensitivity test, using Schiff Sensitivity Scale (SSS) after 8 weeks | 8 Weeks | This will be assessed using Schiff Sensitivity Scale (SSS) score difference from the baseline, that will be determined immediately before product use and then after 8 weeks of daily brushing with the test sensitive toothpaste. Tooth sensitivity score was assessed by air-blast sensitivity, using Schiff Sensitivity Scale (SSS) as follows: 0 = Subject does not respond to air stimulus, 1 = Subject responds to air stimulus but does not request discontinuation of stimulus, 2 = Subject responds to air stimulus and requests discontinuation or moves from stimulus, 3 = Subject responds to air stimulus, considers stimulus to be painful, and requests. |
Countries
Saudi Arabia
Outcome results
None listed