Pulmonary Hypertension
Conditions
Keywords
MRI, oxygen enhanced, fourier decomposition
Brief summary
A prospective study of the use of two novel MRI techniques (oxygen-enhanced and fourier decomposition MRI) in the initial diagnosis and follow-up of patients with Pulmonary Hypertension. The investigators believe these techniques may present a novel set of imaging biomarkers that may be used for risk stratification, prediction of treatment response and longitudinal disease monitoring. The reserach MRI is in addition to standard of care and will not affect treatment decisions.
Interventions
DIAGNOSTIC_TESTMRI
Oxygen enhanced and fourier decomposition MRI
Sponsors
Royal Brompton & Harefield NHS Foundation Trust
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Confirmed diagnosis of Pulmonary Hypertension. * Age 18 and over.
Exclusion criteria
* Standard contra-indications to MRI (as per NHS MRI safety questionnaire). * Not medically fit for transfer to MRI. * Patient judged inappropriate for involvement in study by clinical team e.g. secondary to emotional burden of recent diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delta pO2 max (mmHg) | Baseline and 3-6 months |
| Wash in and wash out time constants (min) | Baseline and 3-6months |
| Signal Intensity Change (%) | Baseline and 3-6months |
| Fractions (% area of lung imaged) | Baseline and 3-6 months |
Countries
United Kingdom
Contacts
Primary ContactPatrik Pettersson
Outcome results
None listed