Myocardial Infarction
Conditions
Keywords
troponin
Brief summary
The rising number of patients with chest pain without myocardial infarction has made accurate diagnosis important. Unnecessary invasive coronary angiographies are increasingly prevalent. These are both costly and lead to rare but serious adverse events. Recent studies suggest cardiac Troponin I is more cardiac specific than cardiac Troponin T. In this study we will investigate whether using cardiac Troponin I lead to fewer unnecessary procedures in clinical practice (i.e. invasive coronary angiography and non-invasive tests)
Interventions
DIAGNOSTIC_TESTTroponin T and I
Does the use of troponin T or I increase the number of patients referred to coronary angiography
Sponsors
Herlev Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Admitted to either Herlev-Gentofte or Amager-Hvidovre Hospital * Clinically suspected of NSTEMI * Referred to invasive coronary angiography (ICA) * Recieved at least one measurement of either troponin
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Specificity for MI | 0 | The difference in specificity of cardiac Troponin and I in detecting patients with significant CAD. The specificity will be defined as the proportion of patients with no significant CAD on ICA correctly identified as low-risk patients and not referred to ICA upon the review by the senior cardiologists |
| Cost-effectiveness | 0 | The cost-effectiveness of using cardiac Troponin T compared to cardiac Troponin I. This will be defined by the number of patients sent to ICA and the associated costs of this. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity for MI | 0 | A safety outcome of difference in sensitivity of cardiac Troponin T and cardiac Troponin I in the detection of patients with significant coronary artery disease. The sensitivity is defined as the proportion of patients with significant coronary artery disease that were referred to ICA upon review by the senior cardiologists |
| Elevated troponin without CAD | 0 | The difference in the proportion of patients with elevated cardiac Troponin T or cardiac Troponin I above the 99th percentile with no significant CAD on ICA |
| Number of MIs | 0 | The difference in the number of patients diagnosed with MI for each cardiac Troponin |
| PPV and NPV | 0 | The difference in positive predictive value and negative predictive value of each cardiac Troponin |
Countries
Denmark
Contacts
Primary ContactKasper Iversen, Dmsc
Outcome results
None listed