Risk Factor
Conditions
Keywords
Clostridium difficile, Multidrug resistant bacteria, Risks factor, highly resistant bacteria, eXDR, ESBL
Brief summary
The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care for carriers these patients
Detailed description
CODBAHRE is a french, regional study, involving 9 centers. Recruitment will take place in all the departments of the centers involved under the supervision of the Infection Control Team. All patients hospitalized more than 24 hours, on a given day are eligible for the protocol, except the patients unable to answer the questionnaire. After collecting the non-opposition of the patient, patients will be screened by rectal swab and a questionnaire will be completed. Each sample will be analyzed to detect eXDR carrying patients. The carrying patients will be followed during 6 months to estimate the proportion of the population which developped a bacterial infection. This information will be collected by a retrospective telephone survey of carrying patients.
Interventions
None listed
Sponsors
Direction Générale de l'Offre de Soins
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Hospitalization of more than 24 hours * Give his no objection
Exclusion criteria
* Hospitalization in psychiatry * Unwilling to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors | at inclusion | Identification of risk factors for digestive colonisation by highly resistant bacteria Lifestyle questionnaire: environment, diet, medical history and result of the rectal swab |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of co-carrying patients of eXDR and ESBL will be determined by the number of patients who carrying eXDR and ESBL referred to the number of patients sampled | 1 day | Estimate the prevalence of co-carrying patients of eXDR and ESBL in the Ile de France |
| Prevalence will be determined by the number of patients who carrying at least one Multidrug-resistant bacteria referred to the number of patients sampled | 1 day | Establish whether there are significant differences between hospital associated with the recruitment of these institutions. |
| Proportion of patients carrying eXDR who will develop an infection with the same germ referred to the number of eXDR carriers | 6 months | Estimate the proportion of patients colonized by a eXDR who will develop an infection with the same germ. |
| Prevalence of multidrug-resistant bacteria will be determined by the number of patients who have been detected at least one multidrug-resistant bacteria referred to the number of patients sampled | 1 day | Number of patient carrying a Multidrug-resistant bacteria in Ile de France |
| Description of the association between strains (RAPD, infrared Biotyper, genome sequencing). | 16 months | Identify possible links between strains |
| Description of resistance and virulence characteristics between strains (RAPD, infrared Biotyper, genome sequencing). | 16 months | Characterize the resistance and virulence factors of certain strains. |
| Comparison of the frequency of positive presence of eXDR bacteria obtained between culture technic and molecular biology technic | 16 months | Comparison culture vs molecular biology technics. |
| Cross-transmission rate of eXDR | 1 day | Number of cross transmissions during the study by comparing the eXDR bacteria genotypes in the same unit |
Countries
France
Outcome results
None listed