Healthy
Conditions
Brief summary
Previous research has demonstrated that the food found in Quorn 'Mycoprotein' can lower the blood glucose response to a meal, which may be an important finding for the management of type 2 diabetes. However, it has never been investigated how this lower response occurs, and whether there is dose-dependent response with mycoprotein. The present study will include 12 healthy young adults, who will visit the laboratory for 3 test days, with each day lasting 9 hours. On each visit, separated by a washout period of at least 2 weeks, participants will ingest either a control drink with no mycoprotein, a drink containing 20g mycoprotein or a drink containing 40g mycoprotein. By intravenously infusing labelled glucose during each visit in combination with repeated blood sampling, investigators will determine if the lower blood glucose after mycoprotein ingestion is due to reduced glucose absorption from the gut or increased uptake into body tissues.
Interventions
DIETARY_SUPPLEMENTMycoprotein Ingestion
Ingestion of various doses of mycoprotein compared to placebo control
Sponsors
Quorn
University of Exeter
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Masking description
Double blind crossover design
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female * 18-35 years of age * Consumption of sufficient amounts of carbohydrate in the diet * Body mass index between 18.5 and 30
Exclusion criteria
* Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes), or other form of abnormal glucose metabolism (as this will affect outcome of the study). * Any diagnosed cardiovascular disease * Insufficient consumption of carbohydrate in the diet * A personal or family history of epilepsy, seizures or schizophrenia * Known pre-existing liver disease/condition * Allergy or intolerance to milk
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose absorption | 6 hours following ingestion of drink | How glucose is absorbed following the ingestion of a mycoprotein drink compared to a placebo control measured using the infusion of stable isotopes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incretin Hormones | 6 hours following ingestion of drink | Measurement of glucagon-like peptide-1(GLP-1) and gastric inhibitory polypeptide (GIP) in response to mycoprotein ingestion compared to placebo control |
| Insulinaemic Response | 6 hours following ingestion of drink | Measurement of insulin response following ingestion of drinks |
| Production of Short-Chain Fatty Acids | 6 hours following ingestion of drink | Measurement of plasma acetate production in response to mycoprotein ingestion |
| Glucose Kinetics | 6 hours following ingestion of drink | Calculations using plasma deuterated glucose enrichment to determine rate of appearance of endogenous glucose, rate of disappearance of glucose and rate of appearance of exogenous glucose |
Countries
United Kingdom
Outcome results
None listed