Anorexia Nervosa
Conditions
Keywords
Anorexia nervosa, Eating disorder, Adolescents, Inpatient treatment, Integrative medicine, Anthroposophic medicine, Heart rate variability, Thermography
Brief summary
A study to assess changes in mental and physical symptoms in adolescent inpatients with anorexia nervosa, a severe eating disorder.
Detailed description
This is a prospective controlled trial to assess changes in psycho-physiological parameters, including eating disorder features (drive for thinness, body dissatisfaction) and comorbid symptoms such as anxiety, depression and quality of life as well as heart rate variability, body warmth and BMI in adolescent inpatients with anorexia nervosa. Parameters were assessed at admission, six weeks after admission and three months thereafter and compared to reference values of healthy controls.
Interventions
OTHERIntegrative medicine-based multimodal treatment
Multimodal inpatient treatment program based on anthroposophic medicine, including individual and group psychotherapy, family therapy, art therapies and specific nursing applications such as embrocations, rhythmical massage and oil dispersion baths.
Sponsors
Die Filderklinik, Filderstadt, Germany
ARCIM Institute Academic Research in Complementary and Integrative Medicine
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
11 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 11-18 years * Restrictive subtype of adolescent AN * Fulfilling the AN diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV and V) * Admitted to the Filderklinik for inpatient treatment
Exclusion criteria
* Patients diagnosed with the binge-purge subtype of adolescent AN or with other eating disorders * Healthy controls: BMI beyond the defined norm for their age group * Healthy controls: acute or chronic disorders including psychiatric disorders, heart defects, cardiac arrhythmia, other disorders requiring medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Drive for Thinness | At admission (timepoint 1, t1), six weeks after admission (t2), and three months after t2 (t3) | Assessed with the 7-item subscale Drive for Thinness of the self-reporting Eating Disorder Inventory-2 at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
| Change in Body Dissatisfaction | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Assessed with the 9-item subscale Body Dissatisfaction of the self-reporting Eating Disorder Inventory-2 at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SF-12 physical | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Physical health-related quality of life, assessed with the 6-item subscale Physical Health of the self-reporting Health-Related Quality of Life Questionnaire (SF-12) at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
| SF-12 mental | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Mental health-related quality of life, assessed with the 6-item subscale Mental Health of the self-reporting Health-Related Quality of Life Questionnaire (SF-12) at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
| SF-12 global | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Overall health-related quality of life, assessed with the self-reporting 12-item Health-Related Quality of Life Questionnaire (SF-12 sum-score) at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
| Anxiety | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Assessed with the 7-item subscale Anxiety of the self-reporting Hospital Anxiety and Depression Scale at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
| Heart rate | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Heart rate (beats/min), derived from 24h ECG recordings |
| Heart rate variability: SDNN | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Standard deviation of normal to normal (NN) intervals (ms), derived from 24h ECG recordings |
| Body warmth | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Body surface temperature (°C) at the inner canthi of both eyes, measured with high-resolution infrared thermography at admission (t1), six weeks after admission (t2) and three months after t2 (t3) |
| Weight gain | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Change in BMI (kg/m2) based on body weight measurements taken at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
| Depression | At admission (t1), six weeks after admission (t2), and three months after t2 (t3) | Assessed with the 7-item subscale Depression of the self-reporting Hospital Anxiety and Depression Scale at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3) |
Countries
Germany
Outcome results
None listed