Intensive Care Unit
Conditions
Keywords
Mitochondrial DNA, Sepsis, Continous venovenous hemofiltation, Intensive Care Unit
Brief summary
The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）
Detailed description
Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .
Interventions
PROCEDUREcontinous venovenous hemofiltraion
CVVH
Sponsors
First People's Hospital of Chenzhou
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Adult septic patients undergoing CRRT
Exclusion criteria
1. Missing vists 2. transplatation 3. cancer 4. aquired immunodeficiency syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of mtDNA concentration in plasma | befor,6hours, 12hours, after CVVH treatment | The specimens in the prefilter and postfilter blood as well as in the ultrafiltrate were obtained at the beginning of CRRT (T0) and 6 h (T6h), 12 h (T12h) after the setup of CVVH. |
Countries
China
Outcome results
None listed