Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery

Does Meal Texture Have Different Impact on Glucose Metabolism and Intestinal Hormone Response After Gastric Bypass and Sleeve Gastrectomy Operated Patients?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04082923

Acronym

Obesity

Enrollment

Registered

2019-09-10

Start date

2019-10-03

Completion date

2021-05-01

Last updated

2021-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucose Metabolism Disorders, Obesity, Sleeve Gastrectomy, Gastric Bypass, Gut Hormones

Brief summary

The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.

Interventions

OTHERLiquid meal

Four-hour liquid mixed meal test

OTHERSolid meal

Four-hour solid mixed meal test

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age \> 18 years * RYGB or SG operation \> 12 months prior to inclusion * Weight stable (± 3 kg during the last month) * HbA1c \< 48 mmol/mol before surgery, and no history of diabetes * HbA1c \< 48 mmol/mol and fasting plasma glucose \< 6.1 mmol/l at inclusion

Exclusion criteria

* Thyrotoxicosis or inadequately treated hypothyreosis * Hemoglobin \< 6.5 mmol/l at inclusion * Pregnancy or breast feeding * Medication affecting the planned examinations

Design outcomes

Primary

Measure	Time frame	Description
GLP-1 response	240 minutes	GLP-1 response after a liquid meal test compared to a solid meal test

Secondary

Measure	Time frame
Difference in gut hormone response after bariatric surgery	240 minutes

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026