Tooth Extraction, Post-Op Complication, Amoxicillin
Conditions
Keywords
tooth extraction, antibiotics, probiotics, tooth infection, complications
Brief summary
Evaluation of the efficacy of amox+clav and of a probiotic after tooth extraction. the aim is to evaluate efficacy of antibiotic therapy after tooth extractions in preventing infections as compared to no therapy, and efficacy of probiotics in preventing gastro-intestinal adverse effects during the antibiotic treatment. The number of patients to be included is 150. The study products are: Amoxicillin + Clavulanic Acid and Bifidobacterium Longum and Lactoferrin.
Detailed description
The main objective of this trial is to evaluate the efficacy of the antibiotic after tooth extraction in preventing infections and to evaluate the effect of probiotic in reducing the possible antibiotic side effects. In order to analyze the effect of the antibiotic in terms of patient's general discomfort, a tailored form was prepared (Appendix A). The local signs and symptoms to evaluate are swelling, pain (assessed by the Visual Analogic Scale), presence of abscess, fever, post-extraction dental alveolitis (dry socket) and presence of trismus assessed as maximal mouth opening variation (mm). In addition adverse post-extraction events will be evaluated as follows: chewing impairments (assessed by the Visual Analogic Scale), speaking impairments (assessed by the Visual Analogic Scale), daily oral hygiene maneuvers impairments (assessed by the Visual Analogic Scale) and daily activities alterations (days-off from job/study). Moreover, the patients will be provided with a painkiller's prescription and they are required to take note of the painkillers needed during the first 7 days, i.e. until the first time point recall. The prescribed painkillers will be Ibuprofen 600 mg or naproxen sodium 500mg for those patients who reported allergy to ibuprofen. Finally, it will be a researcher duty to ask the patients if they needed to assume painkillers beyond the 7th day. Since the post-surgical sequelae depend also on the difficulty of extraction, the Appendix A provides a table in which the surgeon can take note of the type of extraction.
Interventions
tooth extractions are performed for all groups and antibiotics prescribed according to the allocation to the different arms
DIETARY_SUPPLEMENTBifidobacterium longum and Lactoferrin
Sponsors
Antonio Barone
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who needed tooth extractions * Patients older than 18 years * Patients able to understand and to sign a consent form
Exclusion criteria
* General contraindications to oral surgery * Third molar or impacted tooth extractions * Patients treated or under treatment with immunosuppressive agents or patients immunocompromised * Patients treated or under therapy with amino-bisphosphonate and anti-angiogenetic intravenous medications * Patients who received head and neck irradiation treatments * Patients who were diagnosed with uncontrolled diabetes * Patients suffering from renal failure * Pregnancy and breastfeeding patients * Patients diagnosed with drug and alcohol addiction * Patients who suffer from psychiatric disorders * Patients diagnosed with allergy to penicillin and probiotic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of post-operative infection after tooth extractions | 21 days | infection, presence or absence of pus drainage |
| Rate of post-operative alveolar osteitis after tooth extractions | 21 days | alveolar osteitis, presence or absence of exposed bone |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| gastrointestinal symptoms | 21 days | presence of abdominal pain, abdominal distension, nausea, vomit, acid reflux, gastric acidity, gastric pain, intestinal pain, gastric distension, intestinal distension and diarrhea |
Outcome results
None listed