Myocardial Bridge of Coronary Artery
Conditions
Keywords
Coronary abnormalities, Angina, Global longitudinal strain, Speckle-traking echocardiography, Myocardial ischemia
Brief summary
To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal medical therapy (OMT).
Detailed description
The present study is enrolling all the MBs-patients who underwent angina surgical relief or medical treatment at the Ospedali Riuniti of Ancona, Italy, and the University Hospital of Chieti, Italy. All the participants will be examined utilizing echocardiography before and after the treatment. The two-dimensional speckle-tracking analysis will be performed with an off-line dedicated software from the apical 4-chambers-view. All the unroofing procedures will be performed under cardiopulmonary bypass.
Interventions
PROCEDURESurgical unroofing of muscle-briged coronary artery
Medical therapy with beta-blockers or calcium-channels blockers
Sponsors
Azienda Ospedaliero, Universitaria Ospedali Riuniti
ITAB - Institute for Advanced Biomedical Technologies
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Myocardial bridge of the anterior descending left coronary artery
Exclusion criteria
* Poor echocardiographic imaging quality
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of myocardial function and contractility | 1 to 6 month after the procedure/treatment optimizzation | The increment of global longitudinal strain analysis, from pre treatment values, as assessed by speckle-traking echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Angina relief after surgical treatment | 1-month | Defined as the reduction of CCS-Angina Scale, assessed by physicians, from grade I (ordinary physical activity does not cause angina, such as walking and climbing stairs) to grade IV (inability to carry on any physical activity without discomfort, anginal syndrome may be present at rest). The scale comprises 4 degrees in increasing order of angina severity. |
| Improvement in quality of life | 1-month | Defined as the score increment, from 0 to 100 of the SAQ-7 questionnaire. The SAQ quantifies patients' physical limitations caused by angina, the frequency of and recent changes in their symptomstheir satisfaction with treatment, and the degree to which they perceive their disease to affect their quality of life. The questionnaire provides 7 different items with 6 different multiple choices. Each scale is transformed to a score of 0 to 100, where higher scores indicate better function (eg, less physical limitation, less angina, and better quality of life). |
Countries
Italy
Outcome results
None listed