Primary Congenital Glaucoma
Conditions
Brief summary
To present the histopathological features of the iris tissue in primary congenital glaucoma which may play a role in pathogenesis
Detailed description
Primary congenital glaucoma etiology still remains obscure . originally barkan , and later Worst , proposed that a membrane covered the anterior chamber angle and blocked aqueous outflow , but the presence of that membrane has not been established histopathologically to date . Now most authors believe that the site of obstruction is the trabecular meshwork rather than an overlying membrane . Maldevelopment of the anterior segment is present in all forms of congenital glaucoma . this maldevelopment may involve the trabecular meshwork alone or the trabecular meshwork in combination with the iris or cornea or both. In approcimately 50% of patients , isolated trabeculodysgensis is the only developmental ocular anomaly found .This is the classic defect found in primary congenital glaucoma .These eyes have no developmental anomalies of iris or cornea present except abnormal insertion of the iris into the angle
Interventions
Combined trabeculotomy-trabeculectomy with mitomycin C Will be done in all cases then histopathological examination of iris tissue to detect the nature of the disease
Sponsors
Assiut University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
7 Days to 1 Years
Healthy volunteers
No
Inclusion criteria
1. Typical symptoms of epiphora , photophobia and blepharospasm 2. corneal diameter \> 13 mm 3. Increased ocular tension \> 25 mmHg UGA using schiotz tonometer
Exclusion criteria
1. Infants with history of previous surgery 2. Secondary glaucoma 3. Glaucoma associated with other congenital anomalies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Present histopathological features of iris tissue in infants with primary congenital glaucoma which may play a role in pathogenesis | 2 years | Histopathological features of iris tissue in infants with primary congenital glaucoma who underwent Combined trabeculotomy-trabeculectomy with mitomycin C |
Contacts
Primary ContactOmar Abdelkarem Hasan, M.B.B.Ch.
Outcome results
None listed