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The AID Study: Artificial Intelligence for Colorectal Adenoma Detection

The AID Study: Artificial Intelligence for Colorectal Adenoma Detection

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04079478
Acronym
AID
Enrollment
700
Registered
2019-09-06
Start date
2019-09-25
Completion date
2019-12-31
Last updated
2020-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer

Keywords

Artificial Intelligence

Brief summary

Colonoscopy is clinically used as the gold standard for detection of colon cancer (CRC) and removal of adenomatous polyps. Despite the success of colonoscopy in reducing cancer-related deaths, there exists a disappointing level of adenomas missed at colonoscopy. Back-to-back colonoscopies have indicated significant miss rates of 27% for small adenomas (\< 5 mm) and 6% for adenomas of more than 10 mm in diameter. Studies performing both CT colonography and colonoscopy estimate that the colonoscopy miss rate for polyps over 10 mm in size may be as high as 12%. The clinical importance of missed lesions should be emphasized because these lesions may ultimately progress to CRC8. Limitations in human visual perception and other human biases such as fatigue, distraction, level of alertness during examination increases such recognition errors and way of mitigating them may be the key to improve polyp detection and further reduction in mortality from CRC. In the past years, a number of CAD systems for detection of polyps from endoscopy images have been described. However, the benefits of traditional CAD technologies in colonoscopy appear to be contradictory, therefore they should be improved to be ultimately considered useful. Recent advances in artificial intelligence (AI), deep learning (DL), and computer vision have shown potential to assist polyp detection during colonoscopy.

Interventions

OTHERAI

Artificial intellignece colonoscopy

Sponsors

Istituto Clinico Humanitas
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

All 40-80 years-old subjects undergoing a colonoscopy.

Exclusion criteria

* subjects with personal history of CRC, or IBD. * patients with inadequate bowel preparation (defined as Boston Bowel Preparation Scale \> 2 in any colonic segment). * patients with previous colonic resection. * patients on antithrombotic therapy, precluding polyp resection. * patients who were not able or refused to give informed written consent.

Design outcomes

Primary

MeasureTime frameDescription
Additional diagnostic yield obtained by AI-aided colonoscopy to the yield obtained by the Standard (high-definition) colonoscopy3 MonthsTo compare the additional diagnostic yield obtained by AI-aided colonoscopy to the yield obtained by the Standard (high-definition) colonoscopy

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026